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膝关节置换手术中的健康状态效用:McKnee的开发与评估。

Health state utilities in knee replacement surgery: the development and evaluation of McKnee.

作者信息

Bennett K J, Torrance G W, Moran L A, Smith F, Goldsmith C H

机构信息

Department of Clinical Epidemiology and Biostatistics, School of Business, McMaster University, Hamilton, Canada.

出版信息

J Rheumatol. 1997 Sep;24(9):1796-805.

PMID:9292806
Abstract

OBJECTIVE

  1. To develop McKnee, a classification system and direct utility measure for health states associated with knee replacement (KR) surgery. 2. To apply McKnee in a before-after study of KR surgery to: (i) gain experience with McKnee in an elderly population; (ii) confirm the practicality and usefulness of the McKnee system; (iii) assess self-health utility one week before and 3 mo after surgery; (iv) evaluate the stability of 3 clinical marker health states describing mild, moderate, and severe knee disability; (v) compare self-health utility scores with Short Form 36 (SF-36).

METHODS

  1. Instrument development: The McKnee modified Health Utilities Index was developed and used to describe self-health and clinical marker health states: the clinical validity of the clinical marker states was evaluated by 5 clinicians involved in the care off KR patients. 2. Instrument evaluation: McKnee and the SF-36 were administered to 48 patients with osteoarthritis one week before and 3 mo after KR surgery.

RESULTS

Before-after study: McKnee was feasible and acceptable in the older patient group studied (mean age in years, SD: 69.9, 8.6). No change in self-health utility (mean, SD) was observed at 3 mo postsurgery: before -0.78, 0.17; after -0.78, 0.21. On the SF-36, only the change scores for pain and health transition were statistically significant. Utilities (mean, SD) for the clinical marker health states were: mild -0.80, 0.20; moderate -0.55, 0.28; and severe -0.48, 0.31. The clinical marker mean utility scores were stable between the baseline and 3 mo assessment, but the intraclass correlation coefficients for individual scores were low.

CONCLUSION

McKnee provides a preference based measure of health related quality of life that can be used to obtain and interpret clinically the knee disability utility scorers needed for cost-utility studies and medical decision-making models about KR surgery. The McKnee system provides a practical and useful method for classifying knee disability health states and obtaining direct measurements of utility scores for selected health states.

摘要

目的

  1. 开发McKnee,一种用于膝关节置换(KR)手术相关健康状态的分类系统和直接效用测量方法。2. 将McKnee应用于KR手术的前后研究,以:(i)在老年人群中积累使用McKnee的经验;(ii)确认McKnee系统的实用性和有用性;(iii)评估手术前一周和术后3个月的自我健康效用;(iv)评估描述轻度、中度和重度膝关节残疾的3种临床标志物健康状态的稳定性;(v)将自我健康效用评分与简短健康调查问卷(SF - 36)进行比较。

方法

  1. 工具开发:开发了McKnee改良健康效用指数并用于描述自我健康和临床标志物健康状态:由5名参与KR患者护理的临床医生评估临床标志物状态的临床有效性。2. 工具评估:在KR手术前一周和术后3个月,对48例骨关节炎患者进行McKnee和SF - 36评估。

结果

前后研究:在研究的老年患者组中(平均年龄,标准差:69.9岁,8.6岁),McKnee是可行且可接受的。术后3个月未观察到自我健康效用(平均值,标准差)的变化:术前 -0.78,0.17;术后 -0.78,0.21。在SF - 36上,只有疼痛和健康转变的变化分数具有统计学意义。临床标志物健康状态的效用(平均值,标准差)为:轻度 -0.80,0.20;中度 -0.55,0.28;重度 -0.48,0.31。临床标志物平均效用评分在基线和3个月评估之间是稳定的,但个体评分的组内相关系数较低。

结论

McKnee提供了一种基于偏好的健康相关生活质量测量方法,可用于在临床上获取和解释成本效用研究及关于KR手术的医疗决策模型所需的膝关节残疾效用评分。McKnee系统为膝关节残疾健康状态的分类以及获取选定健康状态的效用评分直接测量提供了一种实用且有用的方法。

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