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T细胞的复制性衰老：海弗利克极限会导致免疫耗竭吗？

Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?

作者信息

Effros R B, Pawelec G

机构信息

Dept of Pathology and Laboratory Medicine, UCLA School of Medicine 90095-1732, USA.

出版信息

Immunol Today. 1997 Sep;18(9):450-4. doi: 10.1016/s0167-5699(97)01079-7.

DOI:10.1016/s0167-5699(97)01079-7
PMID:9293162
Abstract

Extensive in vitro research on fibroblasts has defined numerous genetic and phenotypic changes associated with replicative senescence. Identification of T-cell replicative senescence as a feature of human immunodeficiency virus (HIV) disease and ageing suggests this phenomenon merits more careful consideration by immunologists, especially with regard to chronic infection, memory and adoptive immunotherapy.

摘要

对成纤维细胞进行的大量体外研究已确定了许多与复制性衰老相关的基因和表型变化。将T细胞复制性衰老确定为人类免疫缺陷病毒（HIV）疾病和衰老的一个特征，这表明免疫学家应更仔细地考虑这一现象，特别是在慢性感染、记忆和过继性免疫治疗方面。

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