de Toffol B, Uchuya M, Michalak S, Corcia P, Hommet C, Autret A
Clinique Neurologique, CHU Bretonneau, Tours.
Rev Neurol (Paris). 1997 Mar;153(2):135-7.
We report the case of a 62-year-old man affected by anti-Hu-associated paraneoplastic encephalomyelitis. The underlying tumor was a neuroendocrine cancer of the rectum expressing Hu antigen. The neurologic presentation was limited to moderate sensitive neuropathy associated with two complex partial seizures (dreamy state) without any further signs of limbic encephalopathy. A paraneoplastic etiology should be considered in patients with moderate symptomatology. Paraneoplastic encephalomyelitis with anti-Hu antibodies is not always associated with small-cell lung cancer.
我们报告了一例62岁男性患抗Hu相关副肿瘤性脑脊髓炎的病例。潜在肿瘤为表达Hu抗原的直肠神经内分泌癌。神经系统表现仅限于中度感觉性神经病变，伴有两次复杂部分性发作（梦幻状态），无边缘性脑病的任何其他体征。症状中度的患者应考虑副肿瘤病因。抗Hu抗体相关的副肿瘤性脑脊髓炎并不总是与小细胞肺癌相关。
