Ostergaard L J, Møller J K, Andersen B, Olesen F
Arhus Universitetshospital, Marselisborg Hospital, medicinsk-epidemisk afdeling.
Ugeskr Laeger. 1997 Aug 18;159(34):5089-92.
The study compared urine and vaginal flush samples, collected by women at home by endocervical and urine swabs obtained from their general practitioners, for their efficacy in the diagnosis of Chlamydia trachomatis infection. The study was a multipractice study in 33 general practices. A total of 222 women aged 18-25 years, who attended the general practitioner for a gynaecological examination, were included. Diagnostic tests-eight per woman-were performed by the polymerase chain reaction and the ligase chain reaction. A test was considered true positive if two tests or more were positive The prevalence of infection was 11.2% (23/205). Test sensitivity in samples obtained by general practitioners, samples obtained at home subjected to polymerase chain reaction, and samples obtained at home subjected to ligase chain reaction were 91%, 96%, and 100% respectively. The corresponding specificities were 100%, 92.9% and 99.5%. It is concluded that the diagnostic efficacy of samples obtained at home is as good as tests obtained by the general practitioner.
该研究比较了女性在家自行采集的尿液和阴道冲洗样本与从全科医生处获取的宫颈拭子和尿液样本在诊断沙眼衣原体感染方面的效果。该研究是一项在33家全科诊所开展的多诊所研究。共有222名年龄在18至25岁之间、前往全科医生处进行妇科检查的女性纳入研究。采用聚合酶链反应和连接酶链反应对每位女性进行八项诊断检测。如果两项或更多检测呈阳性，则该检测被视为真阳性。感染率为11.2%（23/205）。全科医生采集的样本、在家采集并进行聚合酶链反应的样本以及在家采集并进行连接酶链反应的样本的检测敏感性分别为91%、96%和100%。相应的特异性分别为100%、92.9%和99.5%。研究得出结论，在家采集的样本的诊断效果与全科医生采集的样本一样好。
