Asagoe T, Inaba Y, Jusa E R, Kouno M, Uwatoko K, Fukunaga Y
Department of Veterinary Epizootiology, College of Bioresource Sciences, Nihon University, Kanagawa, Japan.
J Vet Med Sci. 1997 Aug;59(8):727-8. doi: 10.1292/jvms.59.727.
The number of plaques formed by equine arteritis virus (EAV) and Aujesky's disease virus (ADV) was reduced to 14% and 5% of the untreated control (100%), respectively, by 10 U/ml of heparin, but could not be reduced below to 13 and 4%, respectively, by use of concentration up to 100 U/ml. An inhibitory effect of heparin, at concentration up to 100 U/ml, was not observed on parainfluenza virus 3 (PIV-3). Heparinase treatment of RK13 cells reduced the number of EAV-, as well as ADV-induced plaques. On the other hand, the number of PIV-3 induced plaques did not decrease after treatment of RK13 cells with heparinase.
10 U/ml的肝素可使马动脉炎病毒（EAV）和奥耶斯基氏病病毒（ADV）形成的噬斑数量分别降至未处理对照（100%）的14%和5%，但使用浓度高达100 U/ml时，噬斑数量分别无法降至13%和4%以下。在浓度高达100 U/ml时，未观察到肝素对副流感病毒3型（PIV-3）有抑制作用。用肝素酶处理RK13细胞可减少EAV和ADV诱导的噬斑数量。另一方面，用肝素酶处理RK13细胞后，PIV-3诱导的噬斑数量并未减少。
