Johansen M V, Bøgh H O, Giver H, Eriksen L, Nansen P, Stephenson L, Knudsen K E
Danish Centre for Experimental Parasitology, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark.
Parasitology. 1997 Sep;115 ( Pt 3):257-64. doi: 10.1017/s0031182097001327.
The aim of the study was to measure the impact of Schistosoma japonicum and Trichuris suis infections in young growing pigs fed low- or high-protein diets. Thirty-two pigs. 6-10 weeks old, were randomly allocated to 2 groups receiving either a high- or a low-protein diet. After 11 weeks half of the pigs from each group were infected with 1500 S. japonicum cercariae and 4000 T. suis eggs. The weight of the pigs was measured throughout the study, and blood and faecal samples were collected every second week from the time of infection. At the time of infection the low-protein pigs had significantly lower mean body weights, haemoglobin and albumin levels compared with the high-protein pigs, and this pattern continued throughout the study. The serum albumin concentration was further significantly reduced in the infected low-protein pigs compared to the non-infected low-protein pigs. Significantly more S. japonicum worms as well as faecal and tissue eggs were found in the low-protein pigs compared with the high-protein pigs. No differences between the 2 diet groups were observed in T. suis establishment rates or faecal egg excretion. We conclude that this low-protein diet increased the establishment rates of S. japonicum, favoured larger deposits of S. japonicum eggs in the liver and faecal egg excretion, reduced weight gains and caused anaemia and hypoalbuminaemia in young growing pigs as compared with a high-protein diet.
本研究的目的是测定日本血吸虫和猪鞭虫感染对饲喂低蛋白或高蛋白日粮的生长育成仔猪的影响。32头6 - 10周龄的仔猪被随机分为两组，分别接受高蛋白或低蛋白日粮。11周后，每组半数仔猪感染1500条日本血吸虫尾蚴和4000枚猪鞭虫卵。在整个研究过程中测量仔猪体重，并从感染时起每隔一周采集血液和粪便样本。感染时，低蛋白组仔猪的平均体重、血红蛋白和白蛋白水平显著低于高蛋白组仔猪，且这种模式在整个研究过程中持续存在。与未感染的低蛋白组仔猪相比，感染的低蛋白组仔猪血清白蛋白浓度进一步显著降低。与高蛋白组仔猪相比，低蛋白组仔猪体内发现的日本血吸虫虫体以及粪便和组织中的虫卵明显更多。在猪鞭虫的定植率或粪便虫卵排泄方面，未观察到两组日粮之间存在差异。我们得出结论，与高蛋白日粮相比，这种低蛋白日粮增加了日本血吸虫的定植率，有利于日本血吸虫卵在肝脏中的大量沉积和粪便虫卵排泄，降低了体重增加，并导致生长育成仔猪贫血和低白蛋白血症。
