黑升麻中的含氮成分：化学、结构解析及生物活性
Nitrogen-Containing Constituents of Black Cohosh: Chemistry, Structure Elucidation, and Biological Activities.
作者信息
Nikolić Dejan, Lankin David C, Cisowska Tamara, Chen Shao-Nong, Pauli Guido F, van Breemen Richard B
机构信息
UIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612-7231, USA.
出版信息
Recent Adv Phytochem. 2015;45:31-75. doi: 10.1007/978-3-319-20397-3_2.
The roots/rhizomes of black cohosh ( L. syn. [L]. Nutt., Ranunculaceae) have been used traditionally by Native Americans to treat colds, rheumatism, and a variety of conditions related to women's health. In recent years black cohosh preparations have become popular dietary supplements among women seeking alternative treatments for menopausal complaints. The popularity of the plant has led to extensive phytochemical and biological investigations, including several clinical trials. Most of the phytochemical and biological research has focused on two abundant classes of compounds: the triterpene glycosides and phenolic acids. A third group of phytoconstituents that has received far less attention consists of the alkaloids and related compounds that contain nitrogen. This chapter summarizes the current state of knowledge of the chemistry and biological activities associated with this group of constituents and provides some perspective on their significance for future research on this interesting plant.
黑升麻（毛茛科，L. 同物异名 [L.] Nutt.）的根状茎在传统上被美洲原住民用于治疗感冒、风湿病以及各种与女性健康相关的病症。近年来，黑升麻制剂在寻求更年期不适替代疗法的女性中成为流行的膳食补充剂。这种植物的流行引发了广泛的植物化学和生物学研究，包括多项临床试验。大多数植物化学和生物学研究都集中在两类丰富的化合物上：三萜糖苷和酚酸。受到关注少得多的第三类植物成分是生物碱及含氮相关化合物。本章总结了与这类成分相关的化学和生物活性的当前知识状态，并对它们在这种有趣植物未来研究中的重要性提供了一些见解。
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