Song H, Saito K, Seishima M, Noma A, Urakami K, Nakashima K
Department of Laboratory Medicine, Gifu University School of Medicine, Japan.
Neurosci Lett. 1997 Aug 15;231(3):175-8. doi: 10.1016/s0304-3940(97)00558-2.
We compared cerebrospinal fluid (CSF) apolipoprotein (apo) A-I and apo E concentrations in early- and late-onset Alzheimer's disease (EOAD (n = 11), LOAD (n = 15), respectively) with those in control subjects (n = 23). CSF apo A-I levels in both EOAD and LOAD were consistent with control subjects. However, CSF apo E levels were significantly lower in EOAD group (mean +/- SD; 2.65 +/- 1.69 mg/l, P < 0.05) and higher in LOAD group (5.90 +/- 1.94 mg/l, P < 0.01) than those in control group (4.16 +/- 1.69 mg/l). In addition, the epsilon4 allele frequency was not different between EOAD and LOAD groups. Although the reason for the difference in CSF apo E concentrations between two groups is unknown, CSF apo E concentration seems to be associated with the pathogenesis of EOAD and LOAD. The rate of apo E production and/or catabolism in the brain may be different between them.
我们比较了早发型阿尔茨海默病（EOAD，n = 11）和晚发型阿尔茨海默病（LOAD，n = 15）患者脑脊液（CSF）中载脂蛋白（apo）A-I和apo E的浓度，并与对照组（n = 23）进行了对比。EOAD组和LOAD组的CSF apo A-I水平与对照组一致。然而，EOAD组的CSF apo E水平显著低于对照组（均值±标准差；2.65±1.69mg/l，P < 0.05），而LOAD组的CSF apo E水平高于对照组（5.90±1.94mg/l，P < 0.01），对照组为（4.16±1.69mg/l）。此外，EOAD组和LOAD组之间的ε4等位基因频率没有差异。虽然两组之间CSF apo E浓度存在差异的原因尚不清楚，但CSF apo E浓度似乎与EOAD和LOAD的发病机制有关。它们大脑中apo E产生和/或分解代谢的速率可能不同。
