Kitamura H, Kawasaki S
First Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Ultrasound Med Biol. 1997;23(6):933-8. doi: 10.1016/s0301-5629(97)00015-x.
To assess ultrasonic measurements for quantitative analysis of red cell aggregation in humans, 50 patients admitted to our hospital were examined without selection. The extent of the aggregates was a assessed by videodensitometry in the subcutaneous vein in the forearm after 2 min of occlusion by manual compression over the skin. Determinants of aggregability were also evaluated by laboratory blood testing to identify potential correlations with ultrasound data. Multiple regression analysis showed that echogenicity was significantly associated with plasma fibrinogen (p < 0.0001), serum total cholesterol (p = 0.0006) and serum protein fraction excluding albumin (p = 0.0049) and was inversely associated with serum total triglyceride (p = 0.0425), but not with age or hematocrit. Ultrasound measurements of red cell aggregation seemed to be useful for the assessment not only for a part of the rheological condition of the blood, but also concomitant changes in plasma macromolecules.
为评估超声测量用于人体红细胞聚集定量分析的情况，我们对我院收治的50例患者进行了无选择性检查。通过在皮肤上手动压迫阻断血流2分钟后，采用视频密度测定法评估前臂皮下静脉中红细胞聚集体的程度。还通过实验室血液检测评估聚集性的决定因素，以确定与超声数据的潜在相关性。多元回归分析表明，回声性与血浆纤维蛋白原（p < 0.0001）、血清总胆固醇（p = 0.0006）和不包括白蛋白的血清蛋白组分（p = 0.0049）显著相关，与血清总甘油三酯呈负相关（p = 0.0425），但与年龄或血细胞比容无关。红细胞聚集的超声测量似乎不仅有助于评估血液流变学状况的一部分，还能评估血浆大分子的伴随变化。
