Kannagi R, Miyake M, Itai S, Naito M, Hashimoto K
Rinsho Kyobu Geka. 1989 Feb;9(1):19-28.
Recently many monoclonal antibodies are applied in the clinical diagnosis of human cancers. Most of the antigens recognized by these monoclonal antibodies are carbohydrate in their chemical nature. Among these carbohydrate antigens, the sialyl SSEA-1 antigen is particularly useful for the diagnosis of lung cancers, as the elevated serum level of the sialyl SSEA-1 antigen is frequently observed in patients with adenocarcinoma of the lung (ca. 45-75%). Some of the other carbohydrate antigens, such as CA19-9, are also known to be useful for the diagnosis of lung cancers. These carbohydrate antigens are preferentially found in the sera of patients with adenocarcinoma of the lung, while the SCC antigen (TA-4) is closely associated with squamous cell carcinoma of the lung, and NSE (neuron-specific enolase) is frequently detected in the sera of patients with small cell carcinoma of the lung. The specific serum diagnosis of lung cancer of each histological type is now feasible because of the development of these appropriate tumor markers.
近年来，许多单克隆抗体被应用于人类癌症的临床诊断。这些单克隆抗体所识别的大多数抗原在化学性质上是碳水化合物。在这些碳水化合物抗原中，唾液酸化SSEA-1抗原对肺癌的诊断尤为有用，因为在肺腺癌患者中经常观察到唾液酸化SSEA-1抗原的血清水平升高（约45%-75%）。其他一些碳水化合物抗原，如CA19-9，也已知对肺癌的诊断有用。这些碳水化合物抗原优先在肺腺癌患者的血清中发现，而SCC抗原（TA-4）与肺鳞状细胞癌密切相关，NSE（神经元特异性烯醇化酶）经常在肺小细胞癌患者的血清中检测到。由于这些合适的肿瘤标志物的发展，现在对每种组织学类型的肺癌进行特异性血清诊断是可行的。
