特发性炎性肌病中的抗内皮细胞抗体、血栓调节蛋白和血管性血友病因子
Anti-endothelial cell antibody, thrombomodulin, and von Willebrand factor in idiopathic inflammatory myopathies.
作者信息
Salojin K V, Bordron A, Nassonov E L, Shtutman V Z, Guseva N G, Baranov A A, Targoff I N, Youinou P
机构信息
Laboratory of Immunology, Brest University Medical School, France.
出版信息
Clin Diagn Lab Immunol. 1997 Sep;4(5):519-21. doi: 10.1128/cdli.4.5.519-521.1997.
Sera from 19 patients with idiopathic inflammatory myopathy (IIM) were examined for the presence of anti-endothelial cell antibodies (AECA) by an immunoglobulin G-specific cellular enzyme-linked immunosorbent assay. The mean binding index of AECA was found to be 37.7% +/- 26.5% for the patients, compared with a mean of 7.2% +/- 2.7% for normal controls (P < 0.04). Levels of thrombomodulin, von Willebrand factor antigen, and serum creatine kinase were also shown to be augmented. Interestingly, positive correlations between AECA on the one hand and Raynaud's phenomenon and interstitial lung disease on the other were demonstrated. Given that the pathogenesis of IIM remains uncertain, these findings may be of importance.
采用免疫球蛋白G特异性细胞酶联免疫吸附试验，检测了19例特发性炎性肌病（IIM）患者血清中抗内皮细胞抗体（AECA）的存在情况。结果发现，患者AECA的平均结合指数为37.7%±26.5%，而正常对照的平均值为7.2%±2.7%（P<0.04）。血栓调节蛋白、血管性血友病因子抗原水平及血清肌酸激酶水平也显示升高。有趣的是，一方面AECA与雷诺现象及间质性肺病之间存在正相关。鉴于IIM的发病机制仍不确定，这些发现可能具有重要意义。
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