Wei Y, Zhang Y, Derewenda U, Liu X, Minor W, Nakamoto R K, Somlyo A V, Somlyo A P, Derewenda Z S
Nat Struct Biol. 1997 Sep;4(9):699-703. doi: 10.1038/nsb0997-699.
RhoA, a ubiquitous intracellular GTPase, mediates cytoskeletal responses to extracellular signals. A 2.1 A resolution crystal structure of the human RhoA-GDP complex shows unique stereochemistry in the switch I region, which results in a novel mode of Mg2+ binding.
RhoA是一种普遍存在的细胞内GTP酶，介导细胞骨架对细胞外信号的反应。人RhoA-GDP复合物2.1埃分辨率的晶体结构显示，开关I区域具有独特的立体化学结构，这导致了一种新的Mg2+结合模式。
