Keyerleber M A, McEntee M C, Farrelly J, Thompson M S, Scrivani P V, Dewey C W
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Veterinary Cancer Center, Norwalk, CT, USA.
Vet Comp Oncol. 2015 Dec;13(4):385-97. doi: 10.1111/vco.12054. Epub 2013 Jul 19.
Treatment protocols, treatment planning methods and tumour types in studies evaluating radiotherapy for canine brain tumours have been varied. This case series retrospectively evaluated the outcome of definitive, three-dimensional conformal radiation therapy (3D-CRT) as either a sole modality or as an adjuvant to surgery in 31 dogs diagnosed with meningioma by histopathology (n = 10) or cross-sectional imaging of the head (n = 21, assessed independently by two board certified radiologists). Prescribed dose ranged from 45 to 54 Gy in 2.5 to 3 Gy fractions. Median overall survival was 577 days (interquartile range = 272-829 days; range = 30-1942 days) when all deaths were considered and 906 days (interquartile range = 336-912 days; range = 10 -1942 days) when only dogs dying due to meningioma were considered. No significant difference in survival time was detected for the defined clinical or imaging findings or between treatment with radiotherapy alone versus adjuvant radiotherapy, suggesting that 3D-CRT may be a viable alternative to surgery.
在评估犬脑肿瘤放射治疗的研究中，治疗方案、治疗计划方法和肿瘤类型各不相同。本病例系列回顾性评估了31只经组织病理学诊断为脑膜瘤的犬（n = 10）或经头部横断面成像诊断为脑膜瘤的犬（n = 21，由两名获得董事会认证的放射科医生独立评估）接受三维适形放射治疗（3D-CRT）作为单一治疗方式或手术辅助治疗的结果。处方剂量为45至54 Gy，分2.5至3 Gy分次给予。当考虑所有死亡情况时，中位总生存期为577天（四分位间距 = 272 - 829天；范围 = 30 - 1942天），当仅考虑因脑膜瘤死亡的犬时，中位总生存期为906天（四分位间距 = 336 - 912天；范围 = 10 - 1942天）。对于明确的临床或影像学表现，或单独放疗与辅助放疗之间的生存时间，未检测到显著差异，这表明3D-CRT可能是手术的可行替代方案。
