Santos Vicente J
Servicio de Aparato Digestivo, Hospital General Valle de Hebrón, Barcelona.
Rev Esp Enferm Dig. 1997 Jul;89(7):551-8.
Food antigens may play an important role in the etiology of a variety of gastrointestinal conditions ranging from food allergy and malabsorption syndromes to inflammatory bowel disease. However, the prevailing terminological confusion relative to allergy in the last years and in particular on the definition and classification of adverse reactions to foods joined to the absence of definitive diagnostic tests have impeded the investigation of food-allergic reactions. In the last few years the development of animal models and its application to the clinical ground have brought about new light to the mechanisms that regulate the response to antigenic challenge. In particular, the better understanding of the participation of key cellular elements, such as mast cells and basophils, in the modulation of immediate hypersensitivity reactions and the demonstration of the existence of IgE-independent immunologic mechanisms, have rendered new insights for diagnosis and treatment of food allergy.
食物抗原可能在多种胃肠道疾病的病因学中发挥重要作用，这些疾病范围从食物过敏、吸收不良综合征到炎症性肠病。然而，过去几年中关于过敏的普遍术语混乱，特别是关于食物不良反应的定义和分类，再加上缺乏明确的诊断测试，阻碍了对食物过敏反应的研究。在过去几年中，动物模型的发展及其在临床中的应用为调节对抗抗原刺激反应的机制带来了新的曙光。特别是，对关键细胞成分如肥大细胞和嗜碱性粒细胞在调节速发型超敏反应中的作用有了更好的理解，以及对IgE非依赖性免疫机制存在的证明，为食物过敏的诊断和治疗提供了新的见解。
