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[静脉输注氨基酸在全胃肠外营养中对大鼠实验性结肠吻合口愈合的影响]

[The effect of intravenous amino acids in total parenteral nutrition on the healing of experimental colonic anastomoses in the rat].

作者信息

Vázquez Prado A, Aznar Vicente J J, Villalba Ferrer F, Marti Bonmati E, Perkins Wineberger I, García Coret M J, Artigues Sánchez de Rojas E, Fuster Diana C, Montalvá Orón E

机构信息

Centro de Investigación, Hospital General Universitario de Valencia, España.

出版信息

Nutr Hosp. 1997 Mar-Apr;12(2):73-9.

PMID:9303651
Abstract

The authors present a study in two groups of Wistar rats, which were given two different parenteral nutritions with two different amounts of proteins, during different periods of time (4, 7 and 11 days), with the objective of evaluating their influence on the healing of a colonic anastomosis which was performed prior to the initiation of the TPN. To asses the condition of the colonic anastomosis, we studied the rupture pressure of the colon containing the anastomosis, the hydroxyproline concentration of said anastomosis, and the histological study of the same. The results indicate that the group of animals which were fed with a hyperproteinic diet during a longer period of time, showed a better degree of healing than the rest of the study groups.

摘要

作者对两组Wistar大鼠进行了一项研究,在不同时间段(4天、7天和11天)给予它们两种不同蛋白质含量的肠外营养,目的是评估其对在开始全胃肠外营养(TPN)之前进行的结肠吻合口愈合的影响。为了评估结肠吻合口的状况,我们研究了含有吻合口的结肠的破裂压力、该吻合口的羟脯氨酸浓度以及对其进行的组织学研究。结果表明,在较长时间内接受高蛋白饮食喂养的动物组,其愈合程度优于其他研究组。

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