Huang Y T, Cheng Y R, Lin H C, Chen C F, Hong C Y
Institute of TRaditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
J Gastroenterol Hepatol. 1997 Aug;12(8):585-9. doi: 10.1111/j.1440-1746.1997.tb00490.x.
Tetrandrine is a calcium channel antagonist with reported antihypertensive effect. However, the potential role of tetrandrine as a therapeutic agent in portal hypertension has yet to be explored. The present study aimed to investigate the haemodynamic effects of chronic tetrandrine treatment on portal hypertensive rats. Portal hypertension was induced by partial portal vein ligation in Sprague-Dawley rats. Animals were allocated into one of two groups: a tetrandrine group and a vehicle group. Tetrandrine (20 mg/kg) or vehicle was administered by gavage every 12 h for 8 consecutive days, starting 1 day before ligation and continuing thereafter. After 8 days of tetrandrine treatment, systemic haemodynamics, organ blood flow and the degree of portal-systemic shunting were measured after an overnight fast. The portal venous pressure and protal tributary blood flow were significantly decreased, while portal territory as well as hepto-collateral vascular resistance significantly increased in the tetrandrine group compared with the vehicle group. The cardiac index was increased, while systemic vascular resistance was decreased, the the tetrandrine group. Mean arterial pressure, heart rate, portal-systemic shunting and bodyweight were similar between the two groups. Renal blood flow was decreased in the tetrandrine group. In conclusion, long-term treatment of tetrandrine reduced portal venous pressure and alleviated splanchnic hyperaemina in portal hypertensive rats without affecting the portal-systemic shunting.
粉防己碱是一种据报道具有降压作用的钙通道拮抗剂。然而，粉防己碱作为门静脉高压治疗药物的潜在作用尚未得到探索。本研究旨在探讨长期给予粉防己碱对门静脉高压大鼠血流动力学的影响。通过部分门静脉结扎在Sprague-Dawley大鼠中诱导门静脉高压。将动物分为两组之一：粉防己碱组和溶剂对照组。从结扎前1天开始，每12小时通过灌胃给予粉防己碱（20mg/kg）或溶剂，持续8天。粉防己碱治疗8天后，在禁食过夜后测量全身血流动力学、器官血流量和门体分流程度。与溶剂对照组相比，粉防己碱组门静脉压力和门静脉分支血流量显著降低，而门静脉区域以及肝侧支血管阻力显著增加。粉防己碱组心脏指数增加，全身血管阻力降低。两组之间平均动脉压、心率、门体分流和体重相似。粉防己碱组肾血流量减少。总之，长期给予粉防己碱可降低门静脉高压大鼠的门静脉压力并减轻内脏充血，而不影响门体分流。
