Huang Y T, Cheng Y R, Lin H C, Chen S M, Hong C Y
Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
J Gastroenterol Hepatol. 1998 Mar;13(3):266-72. doi: 10.1111/j.1440-1746.1998.01554.x.
Octreotide is an effective portal hypotensive drug in the control of variceal bleeding. Tetrandrine is a type of calcium channel blocker recently reported to reduce portal hypertension. The present study was undertaken to investigate the haemodynamic effects of octreotide and tetrandrine, alone and in combination, in portal hypertensive rats. Portal hypertension was induced by partial portal vein ligation. Portal hypertensive rats were allocated into one of the four groups: vehicle group (saline, 0.5 mL/day), octreotide group (100 microg/kg per 12 h), tetrandrine group (20 mg/kg per 12 h), and octreotide (100 microg/kg per 12 h) plus tetrandrine (20mg/kg per 12 h) group. Tetrandrine or saline was administered by gavage, and octreotide by subcutaneous injection. The drug was given for 8 consecutive days, starting 1 day before ligation and continuing onwards. Haemodynamic parameters were measured thereafter, using the radioactive microsphere method. The portal venous pressure and portal tributary blood flow were significantly reduced, while portal territory and renal vascular resistances were significantly enhanced, by octreotide, tetrandrine, or octreotide plus tetrandrine in portal hypertensive rats, compared with the vehicle group. Our results showed that long-term administration of octreotide, tetrandrine, or octreotide plus tetrandrine led to portal hypotensive effects in portal hypertensive rats, but octreotide alone exerted better anti-hyperdynamic effects compared with tetrandrine alone. A combination of octreotide and tetrandrine offered no major beneficial anti-hyperdynamic effects compared with octreotide alone.
奥曲肽是一种控制静脉曲张出血的有效门脉降压药物。粉防己碱是最近报道的一种可降低门脉高压的钙通道阻滞剂。本研究旨在探讨奥曲肽和粉防己碱单独及联合应用对门脉高压大鼠的血流动力学影响。通过部分门静脉结扎诱导门脉高压。将门脉高压大鼠分为四组之一：溶剂对照组（生理盐水，0.5 mL/天）、奥曲肽组（每12小时100μg/kg）、粉防己碱组（每12小时20mg/kg）和奥曲肽（每12小时100μg/kg）加粉防己碱（每12小时20mg/kg）组。粉防己碱或生理盐水通过灌胃给药，奥曲肽通过皮下注射给药。从结扎前1天开始连续给药8天并持续进行。此后，使用放射性微球法测量血流动力学参数。与溶剂对照组相比，奥曲肽、粉防己碱或奥曲肽加粉防己碱可使门脉高压大鼠的门静脉压力和门静脉分支血流量显著降低，而门脉区域和肾血管阻力显著增加。我们的结果表明，长期给予奥曲肽、粉防己碱或奥曲肽加粉防己碱可导致门脉高压大鼠出现门脉降压作用，但单独使用奥曲肽比单独使用粉防己碱具有更好的抗高动力作用。与单独使用奥曲肽相比，奥曲肽和粉防己碱联合应用未产生主要的有益抗高动力作用。
