Huang Y T, Cheng Y R, Lin H C, Chen C F, Hong C Y
Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
Chin J Physiol. 1997 Sep 30;40(3):175-8.
Tetrandrine is a calcium channel antagonist with reported anti-hypertensive effect. The present study aimed to investigate the hemodynamic effects of chronic tetrandrine treatment on normotensive Sprague-Dawley rats. Animals were allocated into one of the two groups: tetrandrine group and vehicle group. Tetrandrine (20 mg/kg) or vehicle was administered by gavage every 12 hours for consecutive 8 days. After 8 days of tetrandrine treatment, systemic hemodynamics and organ blood flows were measured on the next morning after an overnight fast, using radioactive microsphere method. Mean arterial pressure (96 +/- 2 vs. 118 +/- 4 mmHg) and systemic vascular resistance (254 +/- 35 vs. 369 +/- 5 dyn.sec.cm5 x 10(3)/100 g body wt) were significantly decreased in the tetrandine group as compared to the vehicle group. The cardiac-index (35.2 +/- 2.7 vs. 25.5 +/- 0.8 mL/min/100 g body wt) was increased in the tetrandrine group. The portal venous pressure, portal tributary blood flow, portal territory vascular resistance, renal blood flow, renal vascular resistance, heart rate and body weight were similar between the two groups. In conclusion, long-term treatment of tetrandrine reduced mean arterial pressure and systemic vascular resistance but did not change splanchnic or renal hemodynamics in normal rats.
汉防己甲素是一种据报道具有抗高血压作用的钙通道拮抗剂。本研究旨在探讨长期给予汉防己甲素对正常血压的Sprague-Dawley大鼠的血流动力学影响。动物被分为两组之一：汉防己甲素组和溶剂对照组。汉防己甲素（20mg/kg）或溶剂对照组药物每12小时经口灌胃给药，连续8天。在给予汉防己甲素8天后，在禁食过夜后的次日早晨，使用放射性微球法测量全身血流动力学和器官血流量。与溶剂对照组相比，汉防己甲素组的平均动脉压（96±2 vs. 118±4 mmHg）和全身血管阻力（254±35 vs. 369±5 dyn.sec.cm5×10(3)/100 g体重）显著降低。汉防己甲素组的心指数（35.2±2.7 vs. 25.5±0.8 mL/min/100 g体重）升高。两组之间的门静脉压力、门静脉分支血流量、门静脉区域血管阻力、肾血流量、肾血管阻力、心率和体重相似。总之，长期给予汉防己甲素可降低正常大鼠的平均动脉压和全身血管阻力，但不改变内脏或肾脏的血流动力学。
