Frisbie D D, Kawcak C E, Trotter G W, Powers B E, Walton R M, McIlwraith C W
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA.
Equine Vet J. 1997 Sep;29(5):349-59. doi: 10.1111/j.2042-3306.1997.tb03138.x.
The objective of this study was to determine the effects of intra-articularly administered triamcinolone acetonide (TA) in exercised equine athletes with carpal osteochondral fragmentation. Eighteen horses were randomly assigned to each of 3 groups. An osteochondral chip fragment was created in one randomly chosen intercarpal joint of each horse. Both intercarpal joints in the placebo control group (CNT) horses were injected with intra-articular administration (IA) of polyionic fluid. Both joints in the TA control group (TA CNT) horses were treated with 12 mg of TA in the intercarpal joint without an osteochondral fragment, and the opposite intercarpal joint was injected with a similar volume of polyionic fluid. The TA treated group (TA TX) horses were treated with 12 mg of TA in the joint that contained the osteochondral fragment and the opposite intercarpal joint was injected with a similar volume of polyionic fluid. All horses were treated IA on days 13 and 27 after surgery and exercised on a high speed treadmill for 6 weeks starting on Day 14. Horses in the TA TX group were significantly less lame than horses in the CNT and TA CNT groups. Horses in either TA CNT or TA TX groups had lower total protein, and higher hyaluronan, and glycosaminoglycan concentrations in synovial fluid than did those in the CNT group. Synovial membrane collected from subjects in TA CNT and TA TX groups had significantly less inflammatory cell infiltration, subintimal hyperplasia and subintimal fibrosis compared to the CNT group. Articular cartilage histomorphological parameters were significantly better from the TA CNT and TA TX groups compared to the CNT group. In conclusions, results from this study support favourable effects of TA on degree of clinically detectable lameness, and on synovial fluid, synovial membrane, and articular cartilage morphological parameters, both with direct intra-articular administration and remote site administration as compared to placebo treatment. The clinical use of IA administered TA in horses may be therapeutically beneficial in selected cases of osteochondral fragmentation and osteoarthritis.
本研究的目的是确定关节内注射曲安奈德（TA）对患有腕关节骨软骨碎裂的运动马的影响。18匹马被随机分为3组。在每匹马随机选择的一个腕间关节制造一个骨软骨碎片。安慰剂对照组（CNT）马匹的两个腕间关节均进行关节内注射（IA）聚离子液体。TA对照组（TA CNT）马匹的两个关节中，在没有骨软骨碎片的腕间关节注射12mg TA，对侧腕间关节注射相同体积的聚离子液体。TA治疗组（TA TX）马匹在含有骨软骨碎片的关节注射12mg TA，对侧腕间关节注射相同体积的聚离子液体。所有马匹在术后第13天和第27天接受IA治疗，并从第14天开始在高速跑步机上运动6周。TA TX组的马比CNT组和TA CNT组的马跛行明显减轻。TA CNT组或TA TX组马的滑液中总蛋白含量较低，透明质酸和糖胺聚糖浓度较高，高于CNT组。与CNT组相比，TA CNT组和TA TX组受试者的滑膜炎症细胞浸润、内膜下增生和内膜下纤维化明显减少。与CNT组相比，TA CNT组和TA TX组的关节软骨组织形态学参数明显更好。总之，本研究结果支持TA对临床可检测跛行程度以及滑液、滑膜和关节软骨形态学参数具有有利影响，与安慰剂治疗相比，无论是直接关节内给药还是远程部位给药。关节内注射TA在马中的临床应用在某些骨软骨碎裂和骨关节炎病例中可能具有治疗益处。
