Kawcak C E, Norrdin R W, Frisbie D D, Trotter G W, Mcilwraith C W
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA.
Equine Vet J. 1998 Jan;30(1):66-71. doi: 10.1111/j.2042-3306.1998.tb04090.x.
To determine the effects of osteochondral fragmentation and intra-articular corticosteroid treatment on dynamics of bone remodelling and fragility, 12 horses each had a unilateral, 8 mm osteochondral fragment created in the distal aspect of one radiocarpal bone. Six of the horses were treated in the fragmented joint, and the other 6 were treated in the nonfragmented joint with 12 mg of triamcinolone acetonide (TA) 14 and 28 days after surgery. All horses were exercised on a high-speed treadmill starting 15 days, and ending 72 days after surgery. Horses treated with TA in the fragmented joints were significantly less lame than those treated in the nonfragmented joints. Third carpal bones from joints with fragments showed significantly more vascularity, single labelled surface, total labelled surface and mineralising surface in subchondral and subjacent trabecular bone. Trends were also seen towards higher vascular canal volume and osteochondral junction remodelling sites in third carpal bones from fragmented joints. No significant differences were seen in microdamage density or size between fragmented and nonfragmented joints. No significant influence of TA treatment was seen on any parameter measured. The results from this study show that osteochondral fragmentation induces significant changes in remodelling of opposing bones, and that the administration of corticosteroids into joints with fragmentation does not significantly alter bone remodelling or fragility.
为了确定骨软骨碎片形成及关节内注射皮质类固醇治疗对骨重塑动力学和骨脆性的影响，12匹马每匹马在一侧桡腕骨远端制造一个8毫米的骨软骨碎片。其中6匹马在有碎片的关节进行治疗，另外6匹马在无碎片的关节于术后14天和28天注射12毫克曲安奈德（TA）进行治疗。所有马匹在术后15天开始至72天结束，在高速跑步机上运动。在有碎片的关节接受TA治疗的马比在无碎片的关节接受治疗的马跛行明显减轻。有碎片关节的第三腕骨在软骨下和相邻小梁骨中显示出明显更多的血管、单标记表面、总标记表面和矿化表面。在有碎片关节的第三腕骨中，血管管腔体积和骨软骨交界重塑部位也有增加的趋势。有碎片和无碎片关节之间的微损伤密度或大小没有显著差异。未观察到TA治疗对所测量的任何参数有显著影响。本研究结果表明，骨软骨碎片形成可引起相对骨重塑的显著变化，并且在有碎片的关节内注射皮质类固醇不会显著改变骨重塑或骨脆性。
