Aldenhoff J B, Dumais-Huber C, Fritzsche M, Sulger J, Vollmayr B
Department of Psychiatry, Central Institute of Mental Health, Mannheim, Germany.
J Psychiatr Res. 1997 May-Jun;31(3):315-22. doi: 10.1016/s0022-3956(96)00045-3.
After stimulation of T-lymphocytes from healthy volunteers with the mitogen phytohemagglutinin (PHA) 40% of the cells exhibit an oscillatory increase in intracellular calcium concentration ([Ca2+]i). During depression the number of cells responding to PHA is reduced to 20%. These cells show a marked decrease in [Ca2+]i-reaction to stimulation and flattened oscillations. This reduction of mitogen-induced Ca2+ signals in T-cells of depressed patients appears to be a reliable state marker in depressive illness and is reversed upon successful treatment with interpersonal psychotherapy (IPT).
用促细胞分裂剂植物血凝素（PHA）刺激健康志愿者的T淋巴细胞后，40%的细胞表现出细胞内钙浓度（[Ca2+]i）的振荡性增加。在抑郁期间，对PHA有反应的细胞数量减少到20%。这些细胞对刺激的[Ca2+]i反应明显降低，振荡变平缓。抑郁症患者T细胞中促细胞分裂剂诱导的Ca2+信号的这种减少似乎是抑郁症的一个可靠状态标志物，并且在人际心理治疗（IPT）成功治疗后会逆转。
