Nyui S, Osanai H, Masuoka H, Ohba S, Yoshida Y, Tsutsui T
Department of Surgery, Sapporo Memorial Hospital of Surgery, Japan.
Surg Today. 1997;27(8):753-6. doi: 10.1007/BF02384991.
A 74-year-old woman presented with anal bleeding and a protuberant mass. A biopsy of the mass revealed the proliferation of spindle-shaped cells with melanin pigments, and an abdominoperineal resection was performed, the histology of which confirmed malignant melanoma. Surgery was absolutely noncurative because massive metastases were encountered in the pelvic and paraaortic lymph nodes. However, postoperative chemotherapy, composed of decarbazine (DTIC), vincristine (VCR), and nimustine hydrochloride (ACNU), achieved satisfactory results. The patient has been well without any evidence of recurrence for more than 3 years.
一名74岁女性因肛门出血和肿物突出就诊。肿物活检显示梭形细胞伴黑色素沉着增生，遂行腹会阴联合切除术，组织学检查确诊为恶性黑色素瘤。手术绝对无法治愈，因为在盆腔和主动脉旁淋巴结发现了大量转移灶。然而，由氮烯咪胺（DTIC）、长春新碱（VCR）和盐酸尼莫司汀（ACNU）组成的术后化疗取得了满意效果。患者状况良好，3年多来无任何复发迹象。
