Palefsky J M, Holly E A, Ralston M L, Arthur S P, Hogeboom C J, Darragh T M
Department of Laboratory Medicine, University of California San Francisco 94143, USA.
Genitourin Med. 1997 Jun;73(3):174-80. doi: 10.1136/sti.73.3.174.
To characterise risk factors for abnormal and cytology and anal human papilloma virus (HPV) infection in homosexual/bisexual men with advanced HIV related immunosuppression.
Cross sectional study of men with Centers for Disease Control group IV HIV disease.
The University of California San Francisco, AIDS Clinic.
129 homosexual or bisexual men with group IV HIV disease.
A questionnaire was administered detailing tobacco, alcohol and recreational drug use, medical history, and sexual practices. Anal swabs for cytology and HPV studies were obtained, as was blood for CD4 levels.
Abnormal anal cytology and anal HPV infection.
Abnormal anal cytology was detected in 39% of subjects and anal HPV infection in 93% as measured by polymerase chain reaction (PCR). Risk factors for abnormal cytology in multivariate analysis included HPV 16/18 infection (measured by PCR, RR = 2.1, 95% CI = 1.2-3.5) and intravenous drug use (RR = 1.8, 95% CI = 1.2-2.7). Infection with HPV 6/11 also had significantly elevated RRs in a separate model. Cigarette smoking, alcohol use, recreational drug use, and low CD4 level were associated with abnormal anal cytology in univariate analysis, as was infection with multiple HPV types and high levels of hybrid capture group B viral DNA.
Anal cytological abnormalities and HPV infection are common among homosexual/bisexual men with group IV HIV disease. In this study population, the main risk factors for abnormal cytology were HPV infection and intravenous drug use.
明确晚期HIV相关免疫抑制的男同性恋/双性恋男性肛门细胞学异常及肛门人乳头瘤病毒（HPV）感染的危险因素。
对疾病控制中心IV组HIV疾病男性患者的横断面研究。
加利福尼亚大学旧金山分校艾滋病诊所。
129例患有IV组HIV疾病的男同性恋或双性恋男性。
发放一份问卷，详细询问烟草、酒精及娱乐性药物使用情况、病史和性行为。采集肛门拭子用于细胞学和HPV研究，同时采集血液检测CD4水平。
肛门细胞学异常和肛门HPV感染。
通过聚合酶链反应（PCR）检测，39%的受试者存在肛门细胞学异常，93%存在肛门HPV感染。多变量分析中，细胞学异常的危险因素包括HPV 16/18感染（通过PCR检测，RR = 2.1，95%CI = 1.2 - 3.5）和静脉吸毒（RR = 1.8，95%CI = 1.2 - 2.7）。在另一个模型中，HPV 6/11感染的RR值也显著升高。在单变量分析中，吸烟、饮酒、娱乐性药物使用、低CD4水平与肛门细胞学异常相关，多种HPV类型感染及杂交捕获B组病毒DNA高水平也与之相关。
在患有IV组HIV疾病的男同性恋/双性恋男性中，肛门细胞学异常和HPV感染很常见。在本研究人群中，细胞学异常的主要危险因素是HPV感染和静脉吸毒。
