Irwin M S, Sanders R, Green C J, Terenghi G
Blood McIndoe Centre, Queen Victoria Hospital, Sussex, England.
J R Soc Med. 1997 Aug;90(8):433-8. doi: 10.1177/014107689709000805.
Non-freezing cold injury (trench foot) is characterized, in severe cases, by peripheral nerve damage and tissue necrosis. Controversy exists regarding the susceptibility of nerve fibre populations to injury as well as the mechanism of injury. Clinical and histological studies (n = 2) were conducted in a 40-year-old man with severe non-freezing cold injury in both feet. Clinical sensory tests, including two-point discrimination and pressure, vibration and thermal thresholds, indicated damage to large and small diameter nerves. On immunohistochemical assessment, terminal cutaneous nerve fibres within the plantar skin stained much less than in a normal control whereas staining to von Willebrand factor pointed to increased vascularity in all areas. The results indicate that all nerve populations (myelinated and unmyelinated) were damaged, possibly in a cycle of ischaemia and reperfusion.
非冻伤性冷损伤（战壕足）在严重情况下的特征是周围神经损伤和组织坏死。关于神经纤维群体对损伤的易感性以及损伤机制存在争议。对一名双脚患有严重非冻伤性冷损伤的40岁男性进行了临床和组织学研究（n = 2）。临床感觉测试，包括两点辨别、压力、振动和热阈值，表明大直径和小直径神经均受损。免疫组织化学评估显示，足底皮肤内的终末皮神经纤维染色比正常对照少得多，而血管性血友病因子染色表明所有区域的血管增多。结果表明，所有神经群体（有髓和无髓）均受损，可能是在缺血和再灌注循环中受损。
