Carrozzo M, Carbone M, Gandolfo S, Valente G, Colombatto P, Ghisetti V
Department of Oral Medicine and Periodontology, School of Medicine and Dentistry, University of Turin, Italy.
Oral Oncol. 1997 May;33(3):220-5. doi: 10.1016/s0964-1955(96)00073-5.
Recently, a clinical relationship between oral lichen planus (OLP) and hepatitis C virus (HCV) infection has been suggested, but the role of this virus on the course of OLP is unknown. We report an unusual lingual localisation of verrucous carcinoma arising in a patient with histologically confirmed OLP and HCV infection diagnosed with second generation enzyme-linked immunosorbent assay and recombinant immunoblot assay. Serum HCV-RNA detected using nested reverse transcriptase polymerase chain reaction (RT-PCR) confirm HCV replication. No classical risk factors associated with verrucous carcinoma were present.
最近，有人提出口腔扁平苔藓（OLP）与丙型肝炎病毒（HCV）感染之间存在临床关联，但该病毒在OLP病程中的作用尚不清楚。我们报告了1例疣状癌的罕见舌部定位病例，该患者经组织学确诊为OLP，并通过第二代酶联免疫吸附试验和重组免疫印迹试验诊断为HCV感染。使用巢式逆转录聚合酶链反应（RT-PCR）检测血清HCV-RNA证实HCV复制。不存在与疣状癌相关的典型危险因素。
