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类固醇滥用后无精子症的保守治疗

Conservative management of azoospermia following steroid abuse.

作者信息

Gazvani M R, Buckett W, Luckas M J, Aird I A, Hipkin L J, Lewis-Jones D I

机构信息

Reproductive Medicine Unit, Liverpool Women's Hospital, UK.

出版信息

Hum Reprod. 1997 Aug;12(8):1706-8. doi: 10.1093/humrep/12.8.1706.

DOI:10.1093/humrep/12.8.1706
PMID:9308797
Abstract

As well as athletes and competitive body builders, recreational body builders attending gymnasia are known to abuse anabolic steroids, using doses from 10- to 40-fold above physiological levels. Androgenic steroids induce hypogonadotrophic hypogonadism with associated azoospermia, leading to infertility. Little literature exists on the treatment of steroid-induced azoospermia following the cessation of abuse. We present four cases of steroid-induced azoospermia, its conservative management and eventual return of normal semen density.

摘要

除了运动员和竞技健美运动员外,在健身房锻炼的业余健美运动员也存在滥用合成代谢类固醇的情况,其使用剂量比生理水平高出10至40倍。雄激素类固醇会导致低促性腺激素性性腺功能减退并伴有无精子症,从而导致不育。关于滥用类固醇停止后类固醇诱导的无精子症的治疗,相关文献较少。我们报告了4例类固醇诱导的无精子症病例、其保守治疗方法以及精液密度最终恢复正常的情况。

相似文献

1
Conservative management of azoospermia following steroid abuse.类固醇滥用后无精子症的保守治疗
Hum Reprod. 1997 Aug;12(8):1706-8. doi: 10.1093/humrep/12.8.1706.
2
[Azoospermia in 2 body-builders after taking anabolic steroids].[两名健美运动员服用合成代谢类固醇后出现无精子症]
Ugeskr Laeger. 1995 Feb 20;157(8):1044-5.
3
Reversible hypogonadism and azoospermia as a result of anabolic-androgenic steroid use in a bodybuilder with personality disorder. A case report.一名患有精神障碍的健美运动员使用合成代谢雄激素类固醇导致可逆性性腺功能减退和无精子症。病例报告。
J Sports Med Phys Fitness. 2000 Sep;40(3):271-4.
4
Impact of anabolic androgenic steroids on male sexual and reproductive function: a systematic review.雄激素合成代谢类固醇对男性性功能和生殖功能的影响:系统评价。
Panminerva Med. 2023 Mar;65(1):43-50. doi: 10.23736/S0031-0808.22.04677-8. Epub 2022 Feb 11.
5
The reversibility of anabolic steroid-induced azoospermia.合成代谢类固醇所致无精子症的可逆性。
J Urol. 1995 May;153(5):1628-30.
6
Successful treatment of anabolic steroid-induced azoospermia with human chorionic gonadotropin and human menopausal gonadotropin.用人绒毛膜促性腺激素和人绝经期促性腺激素成功治疗合成代谢类固醇诱导的无精子症。
Fertil Steril. 2003 Jun;79 Suppl 3:1659-61. doi: 10.1016/s0015-0282(03)00365-0.
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[Endocrine effects of doping with androgenic anabolic steroids].[使用雄激素类合成代谢类固醇兴奋剂的内分泌效应]
Tidsskr Nor Laegeforen. 1994 Feb 10;114(4):426-8.
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The deleterious effects of anabolic androgenic steroid abuse on sexual and reproductive health and comparison of recovery between treated and untreated patients: Single-center prospective randomized study.雄激素滥用对性和生殖健康的有害影响,以及治疗和未治疗患者之间的恢复情况比较:单中心前瞻性随机研究。
Andrologia. 2022 Dec;54(11):e14576. doi: 10.1111/and.14576. Epub 2022 Sep 5.
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Concomitant abuse of anabolic androgenic steroids and human chorionic gonadotrophin impairs spermatogenesis in power athletes.合成代谢雄激素类固醇与人体绒毛膜促性腺激素的同时滥用会损害力量型运动员的精子发生。
Int J Sports Med. 2004 May;25(4):257-63. doi: 10.1055/s-2004-819936.
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Duration of azoospermia following anabolic steroids.使用合成代谢类固醇后无精子症的持续时间。
Fertil Steril. 2004 Jan;81(1):226. doi: 10.1016/j.fertnstert.2003.10.001.

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Testosterone Replacement Therapy in the Treatment of Depression.睾酮替代疗法治疗抑郁症
Health Psychol Res. 2022 Nov 26;10(4):38956. doi: 10.52965/001c.38956. eCollection 2022.
2
Understanding and managing the suppression of spermatogenesis caused by testosterone replacement therapy (TRT) and anabolic-androgenic steroids (AAS).了解并管理由睾酮替代疗法(TRT)和合成代谢雄激素类固醇(AAS)引起的精子发生抑制。
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Treatments for people who use anabolic androgenic steroids: a scoping review.
使用合成代谢雄激素类药物者的治疗方法:范围综述。
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Sport, doping and male fertility.运动、兴奋剂与男性生育力。
Reprod Biol Endocrinol. 2018 Nov 12;16(1):114. doi: 10.1186/s12958-018-0435-x.
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Medication patterns and fertility rates in a cohort of anabolic steroid users.一组合成代谢类固醇使用者的用药模式和生育率
Transl Androl Urol. 2018 May;7(Suppl 2):S198-S204. doi: 10.21037/tau.2018.05.05.
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Former Abusers of Anabolic Androgenic Steroids Exhibit Decreased Testosterone Levels and Hypogonadal Symptoms Years after Cessation: A Case-Control Study.合成代谢雄激素类固醇既往使用者在停药数年之后出现睾酮水平降低及性腺功能减退症状:一项病例对照研究。
PLoS One. 2016 Aug 17;11(8):e0161208. doi: 10.1371/journal.pone.0161208. eCollection 2016.
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Recovery of spermatogenesis following testosterone replacement therapy or anabolic-androgenic steroid use.睾酮替代疗法或使用合成代谢雄激素类固醇后精子发生的恢复。
Asian J Androl. 2016 May-Jun;18(3):373-80. doi: 10.4103/1008-682X.173938.
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Anabolic steroids abuse and male infertility.滥用合成代谢类固醇与男性不育。
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Prolonged hypogonadism in males following withdrawal from anabolic-androgenic steroids: an under-recognized problem.男性停用合成代谢雄激素类固醇后出现的长期性腺功能减退:一个未得到充分认识的问题。
Addiction. 2015 May;110(5):823-31. doi: 10.1111/add.12850. Epub 2015 Feb 25.
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Men regret anabolic steroid use due to a lack of comprehension regarding the consequences on future fertility.男性因对未来生育能力的影响缺乏了解而后悔使用合成代谢类固醇。
Andrologia. 2015 Oct;47(8):872-8. doi: 10.1111/and.12340. Epub 2014 Sep 15.