Hanamura I, Wakita A, Harada S, Tsuboi K, Komatsu H, Banno S, Iwaki O, Takeuchi G, Nitta M, Ueda R
Second Department of Internal Medicine, Nagoya City University Medical School.
Intern Med. 1997 Sep;36(9):643-6. doi: 10.2169/internalmedicine.36.643.
We report a case of idiopathic CD4+ T-lymphocytopenia with malignant lymphoma (diffuse large, B-cell type) for which there was no evidence of human immunodeficiency virus type 1 or type 2 infection and no other known causes of immunodeficiency. She had never suffered from any opportunistic infection until the diagnosis of malignant lymphoma was made, and the CD4+ T-lymphocytopenia persisted after complete remission of the lymphoma. As the clinical features and immune status of the patient differed from those associated with the acquired immunodeficiency syndrome (AIDS)-related syndrome, we conclude that immunodeficiency in this case did not contribute to the opportunistic infection but may have been associated with the genesis of malignant lymphoma.
我们报告一例伴有恶性淋巴瘤（弥漫大B细胞型）的特发性CD4⁺T淋巴细胞减少症，该病例无1型或2型人类免疫缺陷病毒感染证据，也无其他已知免疫缺陷病因。在诊断出恶性淋巴瘤之前，她从未患过任何机会性感染，且淋巴瘤完全缓解后CD4⁺T淋巴细胞减少症仍持续存在。由于该患者的临床特征和免疫状态与获得性免疫缺陷综合征（AIDS）相关综合征不同，我们得出结论，该病例中的免疫缺陷并非导致机会性感染的原因，但可能与恶性淋巴瘤的发生有关。
