沙眼衣原体的抗生素敏感性
Antibiotic susceptibility of Chlamydia trachomatis.
作者信息
Blackman H J, Yoneda C, Dawson C R, Schachter J
出版信息
Antimicrob Agents Chemother. 1977 Dec;12(6):673-7. doi: 10.1128/AAC.12.6.673.
Abstract
The antibiotic susceptibility of Chlamydia trachomatis isolates was determined in a tissue culture system. Representatives of all currently recognized serotypes of trachoma-inclusion conjunctivitis agents were tested. Tetracycline and erythromycin yielded similar results, with 1.0 mug/ml preventing chlamydial replication. Rifampin was the most active antibiotic, with 0.25 mug/ml completely suppressing inclusion formation of all strains. Fifty percent end points were usually achieved at one-fourth to one-eighth the 100% suppression level. Penicillin was not as effective, and the assays were often irregular. Antibiotic susceptibility of these chlamydiae was essentially the same, regardless of serotype, anatomic site infected, geographic origin, or antibiotic use in the community.
摘要
在组织培养系统中测定了沙眼衣原体分离株的抗生素敏感性。对所有目前公认的沙眼-包涵体结膜炎病原体血清型的代表菌株进行了检测。四环素和红霉素产生了相似的结果，1.0微克/毫升可阻止衣原体复制。利福平是最有效的抗生素，0.25微克/毫升可完全抑制所有菌株的包涵体形成。半数有效终点通常在100%抑制水平的四分之一到八分之一时达到。青霉素效果不佳，且检测结果常常不稳定。这些衣原体的抗生素敏感性基本相同，无论血清型、感染的解剖部位、地理来源或社区中的抗生素使用情况如何。
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1
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Antimicrob Agents Chemother. 1972 Sep;2(3):242-4. doi: 10.1128/AAC.2.3.242.
2
Emergence of rifampin-resistance in Chlamydia trachomatis.沙眼衣原体中利福平耐药性的出现。
Nature. 1973 Jul 20;244(5412):173-4. doi: 10.1038/244173a0.
3
Chemotherapy of chlamydial infections.衣原体感染的化学疗法。
Adv Pharmacol (1962). 1969;7:253-82.
4
Topical tetracycline and rifampicin therapy of endemic trachoma in Tunisia.突尼斯地方性沙眼的局部四环素和利福平治疗
Am J Ophthalmol. 1975 May;79(5):803-11. doi: 10.1016/0002-9394(75)90740-0.
5
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J Antimicrob Chemother. 1976 Mar;2(1):71-6. doi: 10.1093/jac/2.1.71.
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