Panzone G, Trani A, Ferrari P, Gastaldo L, Colombo L
Biosearch Italia S.p.A., Gerenzano (VA) Italia.
J Antibiot (Tokyo). 1997 Aug;50(8):665-70. doi: 10.7164/antibiotics.50.665.
A novel product, isolated from a culture broth of Actinoplanes ianthinogenes fermented for producing purpuromycin, was purified and its structure established on the basis of physico-chemical data and chemical reactions. The new product resulted to be structurally related to griseorhodins, a group of hydroquinonic antibiotics obtained from Streptomyces californicus. This compound showed a weak activity against Gram-positive and resulted inactive against Gram-negative bacteria and Candida albicans.
从用于生产紫霉素的发酵产黄游动放线菌的培养液中分离出一种新产物，对其进行了纯化，并根据物理化学数据和化学反应确定了其结构。该新产物在结构上与灰紫红菌素有关，灰紫红菌素是从加利福尼亚链霉菌中获得的一组对苯二酚类抗生素。该化合物对革兰氏阳性菌显示出微弱活性，对革兰氏阴性菌和白色念珠菌无活性。
