Liao Jingyang, Tan Jinli, Li Xiaobo, Huang Dan, Wang Lijun, Zhu Liuchong, Chen Zhiyu, Gan Lin, Liu Wenbin, Jin Xiaobao
School of basic medical sciences, Guangdong Pharmaceutical University, Guangzhou, People's Republic of China.
Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, People's Republic of China.
Sci Rep. 2024 Dec 4;14(1):30242. doi: 10.1038/s41598-024-76212-4.
The global rise of multidrug-resistant pathogens, particularly Methicillin-resistant Staphylococcus aureus (MRSA), has become a critical public health concern, necessitating the urgent discovery of new antimicrobial agents. Griseorhodin C, a hydroxyquinone compound isolated from Streptomyces, has demonstrated significant inhibitory effects against MRSA. In this study, we employed a comprehensive approach combining transcriptome and metabolome analyses to investigate the underlying antimicrobial mechanism of Griseorhodin C. Our findings reveal that Griseorhodin C interferes with multiple bacterial metabolic pathways, including those essential for the biosynthesis and metabolism of amino acids, purine metabolism and energy metabolism, ultimately leading to bacterial growth inhibition and cell death. Notably, Griseorhodin C showed superior inhibitory effects compared to the clinical standard, vancomycin, both in vivo and vitro. These results highlight the potential of Griseorhodin C as a promising candidate for the development of new therapeutic strategies aimed at combating MRSA infections. The study underscores the importance of exploring natural products as sources of novel antibiotics in the ongoing fight against antimicrobial resistance.
全球多重耐药病原体的增加，尤其是耐甲氧西林金黄色葡萄球菌（MRSA），已成为一个关键的公共卫生问题，迫切需要发现新的抗菌药物。从链霉菌中分离出的羟基醌化合物灰紫红菌素C已显示出对MRSA有显著的抑制作用。在本研究中，我们采用了转录组和代谢组分析相结合的综合方法来研究灰紫红菌素C的潜在抗菌机制。我们的研究结果表明，灰紫红菌素C干扰了多种细菌代谢途径，包括对氨基酸生物合成和代谢、嘌呤代谢及能量代谢至关重要的途径，最终导致细菌生长抑制和细胞死亡。值得注意的是，在体内和体外实验中，灰紫红菌素C均显示出比临床标准药物万古霉素更优异的抑制效果。这些结果凸显了灰紫红菌素C作为开发对抗MRSA感染新治疗策略的有前景候选药物的潜力。该研究强调了在对抗抗菌药物耐药性的持续斗争中，探索天然产物作为新型抗生素来源的重要性。
