一种新型灰紫红菌素的分离与结构解析

Isolation and structure elucidation of a novel griseorhodin.

作者信息

Stroshane R M, Chan J A, Rubalcaba E A, Garretson A L, Aszalos A A, Roller P P

出版信息

J Antibiot (Tokyo). 1979 Mar;32(3):197-204. doi: 10.7164/antibiotics.32.197.

DOI:10.7164/antibiotics.32.197

Abstract

Three antibiotics possessing cytotoxic properties were isolated from a strain of Streptomyces griseus (FCRC-57). One was found to be identical with griseorhodin A. A second, FCRC-57-U, was found to be identical to griseorhodin C. FCRC-57-G is a new antibiotic structurally related to griseorhodins A and C, and is active against KB cells in vitro. The structure of this new antibiotic was determined using mass spectrometry, proton and carbon nuclear magnetic resonance spectroscopy and synthesis.

摘要

从一株灰色链霉菌（FCRC - 57）中分离出三种具有细胞毒性的抗生素。其中一种被发现与灰紫红菌素A相同。第二种，FCRC - 57 - U，被发现与灰紫红菌素C相同。FCRC - 57 - G是一种在结构上与灰紫红菌素A和C相关的新型抗生素，在体外对KB细胞具有活性。使用质谱、质子和碳核磁共振光谱以及合成方法确定了这种新型抗生素的结构。