Fukutani Y, Sasaki K, Mukai M, Matsubara R, Isaki K, Cairns N J
Department of Neuropsychiatry, Fukui Medical School, Japan.
Psychiatry Clin Neurosci. 1997 Aug;51(4):227-31. doi: 10.1111/j.1440-1819.1997.tb02588.x.
We have investigated morphometrically unaffected neurons, intracellular neurofibrillary tangles (I-NFT) and extracellular neurofibrillary tangles (E-NFT) in eight subdivisions of the hippocampal cortex in two cases of early-onset familial Alzheimer's disease (FAD) and six cases of early-onset sporadic Alzheimer's disease (SAD). The hippocampal subdivisions examined included: CA4, CA3, CA2, CA1, prosubiculum, subiculum and presubiculum (PRE), parasubiculum (PARA) and entorhinal cortex (ENT). CA3, CA2 and CA1 in the FAD cases showed more severe neuronal loss and much greater E-NFT formation than in the SAD cases, while ENT in both the FAD cases showed less neuronal loss and less E-NFT formation. These data suggest that the cornu ammonis is affected more severely than the ENT in the FAD cases. These observations indicate that hippocampal pathology in the FAD cases is qualitatively as well as quantitatively different from that in sporadic cases. These results provide further evidence for pathological heterogeneity in AD, although the number of FAD cases examined is very small.
我们对2例早发性家族性阿尔茨海默病（FAD）和6例早发性散发性阿尔茨海默病（SAD）患者海马皮质的8个亚区中形态学未受影响的神经元、细胞内神经原纤维缠结（I-NFT）和细胞外神经原纤维缠结（E-NFT）进行了研究。所检查的海马亚区包括：CA4、CA3、CA2、CA1、前下托、下托、前内嗅区（PRE）、旁内嗅区（PARA）和内嗅皮质（ENT）。FAD病例中的CA3、CA2和CA1区显示出比SAD病例更严重的神经元丢失和更多的E-NFT形成，而FAD病例中的ENT区神经元丢失较少且E-NFT形成较少。这些数据表明，在FAD病例中，海马角比ENT区受影响更严重。这些观察结果表明，FAD病例中海马的病理学在质和量上均与散发性病例不同。尽管所检查的FAD病例数量非常少，但这些结果为AD的病理异质性提供了进一步的证据。
