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十三肽菌素A、B和C的分离(芽孢杆菌属抗生素的研究。第二十三篇)

Isolation of tridecaptins A, B and C (studies on antibiotics from the genus Bacillus. XXIII).

作者信息

Shoji J, Hinoo H, Sakazaki R, Kato T, Wakisaka Y, Mayama M, Matsuura S, Miwa H

出版信息

J Antibiot (Tokyo). 1978 Jul;31(7):646-51. doi: 10.7164/antibiotics.31.646.

Abstract

Three new antibiotics, tridecaptins A, B and C, were isolated from culture broths of strains of Bacillus polymyxa AR-110, B-2 and E-23, respectively. All are acyl tridecapeptides differing from each other in the fatty acid components and amino acid residues. They are weakly active against Gram-negative and Gram-positive bacteria in vitro and in vivo.

摘要

三种新抗生素,十三肽菌素A、B和C,分别从多粘芽孢杆菌AR - 110、B - 2和E - 23菌株的培养液中分离得到。它们均为酰基十三肽,脂肪酸成分和氨基酸残基各不相同。它们在体外和体内对革兰氏阴性菌和革兰氏阳性菌的活性较弱。

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