Aguado L, del Valle R, Pérez L
Facultad de Psicología, Universidad Complutense, Madrid, Spain.
Neurobiol Learn Mem. 1997 Sep;68(2):189-96. doi: 10.1006/nlme.1997.3773.
Three experiments studied the effectiveness of ketamine acting as an aversive unconditioned stimulus (UCS) in a conditioned flavor aversion procedure. In Experiment 1a, three conditioning trials where sucrose was paired with ketamine produced a weak but significant aversion to sucrose; Experiment 1b showed that this effect was not due to a reduced consumption of sucrose caused by ketamine-induced neophobia. In Experiment 2, acquisition of an aversion to sucrose paired with lithium chloride (LiCl) injections was retarded by prior repeated exposure to LiCl but not to ketamine. These results are not consistent with an interpretation of previous results, showing that ketamine impairs the acquisition of flavor aversions based on LiCl-induced illness, as an example of the UCS preexposure effect.
三项实验研究了氯胺酮在条件性味觉厌恶程序中作为厌恶非条件刺激（UCS）的有效性。在实验1a中，蔗糖与氯胺酮配对的三次条件试验产生了对蔗糖的微弱但显著的厌恶；实验1b表明，这种效应不是由于氯胺酮引起的新恐惧症导致蔗糖摄入量减少。在实验2中，先前反复接触氯化锂（LiCl）而非氯胺酮会延迟对与氯化锂注射配对的蔗糖的厌恶习得。这些结果与对先前结果的一种解释不一致，先前的结果表明氯胺酮会损害基于氯化锂诱发疾病的味觉厌恶的习得，作为非条件刺激预暴露效应的一个例子。
