Kawasaki Y, Maeda Y, Higashima M, Nagasawa T, Koshino Y, Suzuki M, Ide Y
Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
Schizophr Res. 1997 Aug 29;26(2-3):107-15. doi: 10.1016/s0920-9964(97)00055-8.
Twenty-five schizophrenic patients diagnosed by DSM-III-R underwent event-related potentials and magnetic resonance imaging scans. Latency and amplitude of P300 waveform were measured using an auditory odd-ball paradigm. Anterior and posterior volumes of the superior temporal gyrus and medial temporal structure were measured from contiguous coronal images using the level of the mammillary body as an anatomical landmark. Principal component analysis of P300 latency and amplitude disclosed two orthogonal independent factors each: overall latency and residual, and amplitudes from posterior and anterior recordings, respectively. Structural volumes consisted of four orthogonally independent factors: left superior temporal volume, anterior medial temporal volume, right superior temporal volume, and posterior medial temporal volume. The factor score of the P300 amplitude from posterior recordings correlated with the factor score of volumetric changes in the anterior medial temporal structures. The present study failed to replicate a previously reported association between auditory P300 amplitude and superior temporal volume. Furthermore, the factor score of the P300 amplitude was correlated with the severity of clinical ratings of attentional impairments and positive thought disorder. These findings demonstrate that the information processing dysfunction of schizophrenia indicated by reduced P300 amplitude is associated with structural abnormality in the medial temporal lobe.
25名根据《精神疾病诊断与统计手册》第三版修订本（DSM-III-R）诊断为精神分裂症的患者接受了事件相关电位和磁共振成像扫描。使用听觉odd-ball范式测量P300波形的潜伏期和波幅。以上丘脑回和内侧颞叶结构的前后体积通过连续冠状图像测量，以乳头体水平作为解剖标志。对P300潜伏期和波幅进行主成分分析，分别揭示了两个正交独立因素：总体潜伏期和残差，以及后记录和前记录的波幅。结构体积由四个正交独立因素组成：左侧颞上回体积、前内侧颞叶体积、右侧颞上回体积和后内侧颞叶体积。后记录的P300波幅的因素得分与前内侧颞叶结构体积变化的因素得分相关。本研究未能重复先前报道的听觉P300波幅与颞上回体积之间的关联。此外，P300波幅的因素得分与注意力障碍和阳性思维障碍临床评分的严重程度相关。这些发现表明，P300波幅降低所表明的精神分裂症信息处理功能障碍与内侧颞叶的结构异常有关。
