泥螈视网膜中开和关通道的突触组织及离子基础。II. 氯离子依赖性神经节细胞机制。
Synaptic organization and ionic basis of on and off channels in mudpuppy retina. II. Chloride-dependent ganglion cell mechanisms.
作者信息
Miller R F, Dacheux R F
出版信息
J Gen Physiol. 1976 Jun;67(6):661-78. doi: 10.1085/jgp.67.6.661.
Abstract
Extracellular ganglion cell recordings in the perfused mudpuppy eyecup show that a chloride-free (c-f) perfusate abolishes the center and surround excitation of on-center cells, the surround excitation of off-center cells, and the on discharge of on-off cells. These changes in ganglion cell receptive field organization are anticipated in view of the effects of a c-f environment on the neurons which are presynaptic to the ganglion cells. However, chloride-dependent inhibitory postsynaptic (IPS) responses have been observed in on-off ganglion cells. These inhibitory postsynaptic potentials (IPSP's) are preceeded by (ESPS's) exitatory postsynaptic potentials and are apparently mediated by amacrine cells. The light-activated hyperpolarization of off cells is not the result of a chloride-dependent IPSP and probably results from disfacilitation.
摘要
在灌注的泥螈眼杯中进行的细胞外神经节细胞记录显示，无氯（c-f）灌注液会消除on中心细胞的中心和周边兴奋、off中心细胞的周边兴奋以及on-off细胞的on放电。鉴于c-f环境对神经节细胞突触前神经元的影响，可以预期神经节细胞感受野组织的这些变化。然而，在on-off神经节细胞中观察到了氯离子依赖性抑制性突触后（IPS）反应。这些抑制性突触后电位（IPSP）之前是兴奋性突触后电位（ESPS），显然由无长突细胞介导。off细胞的光激活超极化不是氯离子依赖性IPSP的结果，可能是去易化的结果。
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