Werblin F S, Copenhagen D R
J Gen Physiol. 1974 Jan;63(1):88-110. doi: 10.1085/jgp.63.1.88.
Both the "on" and the "on-off" ganglion cells in the mudpuppy retina generate graded responses over a narrow range of log test intensities. Sustained full field or surround backgrounds change the range of center log test intensities that elicits the graded response for both cell types. The on-off, but not the on ganglion cells are further affected by moving or flashing surround backgrounds. These cells are hyperpolarized, threshold is elevated, and the entire graded range of response is elicited by a higher range of log center test intensities. Depolarizing activity is elicited in amacrine cells by moving backgrounds that affect the on-off ganglion cells, but bipolar activity is unaffected. These results suggest that the amacrine cells at the inner plexiform layer mediate a third stage of sensitivity control in the retina, increasing threshold for response to change specifically in the on-off ganglion cells.
泥螈视网膜中的“开”和“开-关”神经节细胞在较窄的对数测试强度范围内产生分级反应。持续的全场或周边背景会改变引发两种细胞类型分级反应的中心对数测试强度范围。“开-关”神经节细胞（而非“开”神经节细胞）会进一步受到移动或闪烁的周边背景影响。这些细胞发生超极化，阈值升高，并且整个分级反应范围由更高范围的对数中心测试强度引发。影响“开-关”神经节细胞的移动背景会在无长突细胞中引发去极化活动，但双极细胞活动不受影响。这些结果表明，内网状层的无长突细胞介导了视网膜敏感性控制的第三阶段，专门提高了对“开-关”神经节细胞变化反应的阈值。
