Reis D J, Regunathan S
Division of Neurology, Cornell University Medical College, New York, New York 10021, USA.
Adv Pharmacol. 1998;42:645-9. doi: 10.1016/s1054-3589(08)60834-0.
Current evidence is consistent with an hypothesis that agmatine meets many criteria for a neurotransmitter-neuromodulator. It is synthesized, stored, and released in brain; is contained in neurons and axon terminals with a heterogeneous distribution; interacts with cell-specific receptors; and elicits biological actions within the central nervous system. Its role in normal brain function, however, has not yet been established, in part because of the absence of agents that selectively affect its biosynthesis or degradation.
目前的证据与胍丁胺符合神经递质-神经调质的许多标准这一假说相一致。它在大脑中合成、储存并释放；存在于神经元和轴突终末，分布不均一；与细胞特异性受体相互作用；并在中枢神经系统内引发生物学作用。然而，其在正常脑功能中的作用尚未确定，部分原因是缺乏选择性影响其生物合成或降解的试剂。
