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1
Crossreactive mixed lymphocyte reaction determinants recognized by cloned alloreactive T cells.克隆化的同种异体反应性T细胞识别的交叉反应性混合淋巴细胞反应决定簇。
Proc Natl Acad Sci U S A. 1979 Nov;76(11):5863-6. doi: 10.1073/pnas.76.11.5863.
2
Clones of alloreactive T cells. I. A. unique homozygous MLR-stimulating determinant present on B6 stimulators.同种异体反应性T细胞克隆。I. A. B6刺激细胞上存在独特的纯合MLR刺激决定簇。
Immunogenetics. 1980;10(2):175-84. doi: 10.1007/BF01561566.
3
Recognition and response to alloantigens in vivo. I. Negative and positive selection of MLR reactivity in murine peripheral blood lymphocytes to major histocompatibility complex and Mls antigens.体内对同种异体抗原的识别与反应。I. 小鼠外周血淋巴细胞对主要组织相容性复合体和Mls抗原的混合淋巴细胞反应性的阴性和阳性选择。
J Immunol. 1984 Aug;133(2):606-15.
4
MHC recognition by clones of Mls specific T-lymphocytes.Mls特异性T淋巴细胞克隆对MHC的识别。
Immunogenetics. 1982;16(3):243-55. doi: 10.1007/BF00343313.
5
Dissection of the poly(glu60 ala30 tyr10) (GAT)-specific T-cell repertoire in H-2Ik mice. I. GAT plus self-I-Ak-reactive T-cell clones can recognize alloactivating and/or restriction determinants on nonself-Ia molecules.H-2Ik小鼠中多聚（谷氨酸60 丙氨酸30 酪氨酸10）（GAT）特异性T细胞库的剖析。I. GAT加自身I-Ak反应性T细胞克隆可识别非自身Ia分子上的同种异体激活和/或限制决定簇。
Immunogenetics. 1983;18(5):475-88. doi: 10.1007/BF00364389.
6
Alloreactive T-cell recognition of two DQ beta allelic specificities associated with DQw1.与DQw1相关的两种DQβ等位基因特异性的同种异体反应性T细胞识别。
Hum Immunol. 1987 Mar;18(3):225-34. doi: 10.1016/0198-8859(87)90087-5.
7
T cell responses to select Ia determinants using the I-A mutant mouse strain B6.C-H-2bm12.使用I-A突变小鼠品系B6.C-H-2bm12对选定Ia决定簇的T细胞应答。
J Immunol. 1982 Nov;129(5):2094-7.
8
Regulation of the in vitro presentation of minor lymphocyte stimulating determinants by major histocompatibility complex-encoded immune response genes.主要组织相容性复合体编码的免疫应答基因对次要淋巴细胞刺激决定簇体外呈递的调控。
J Immunol. 1987 Apr 15;138(8):2392-401.
9
T cell responses to Mls determinants are restricted by cross-reactive MHC determinants.T细胞对Mls决定簇的反应受交叉反应性MHC决定簇的限制。
J Immunol. 1985 Apr;134(4):2071-8.
10
Activation requirements of cloned inducer T cells. III. Need for two stimulator cells in the response of a cloned line to Mls determinants.克隆诱导性T细胞的激活要求。III. 克隆系对Mls决定簇应答中对两种刺激细胞的需求。
J Immunol. 1986 Aug 15;137(4):1109-14.

引用本文的文献

1
Cell-interaction molecules on immunocompetent lymphocytes. Development of anti-parent cell-interaction-molecule-receptor reactions in F1 hybrid mice and evidence for a unique F1 hybrid subset of interacting cells.免疫活性淋巴细胞上的细胞相互作用分子。F1杂种小鼠中抗亲本细胞相互作用分子受体反应的发展以及相互作用细胞独特F1杂种亚群的证据。
J Exp Med. 1981 Feb 1;153(2):407-22. doi: 10.1084/jem.153.2.407.
2
In vitro analysis of allogeneic lymphocyte interaction. V. Identification and characterization of two components of allogeneic effect factor, one of which displays H-2-restricted helper activity and the other, T cell-growth factor activity.同种异体淋巴细胞相互作用的体外分析。V. 同种异体效应因子两种成分的鉴定与特性，其中一种表现出H-2限制性辅助活性，另一种表现出T细胞生长因子活性。
J Exp Med. 1981 Jan 1;153(1):107-28. doi: 10.1084/jem.153.1.107.
3
Analysis of thymocyte MHC specificity with thymocyte hybridomas.利用胸腺细胞杂交瘤分析胸腺细胞的主要组织相容性复合体特异性
J Exp Med. 1984 Sep 1;160(3):799-813. doi: 10.1084/jem.160.3.799.
4
T cell clones specific for hybrid I-A molecules. Discrimination with monoclonal anti-I-Ak antibodies.针对杂交I-A分子的T细胞克隆。用单克隆抗I-Ak抗体进行鉴别。
J Exp Med. 1982 Oct 1;156(4):1186-94. doi: 10.1084/jem.156.4.1186.
5
Lymphocyte-mediated lysis of tumor cells in vitro. Antigen-restricted clonal and unrestricted polyclonal effects.淋巴细胞在体外介导的肿瘤细胞裂解。抗原限制的克隆效应和非限制的多克隆效应。
Springer Semin Immunopathol. 1982;5(2):147-59. doi: 10.1007/BF00199793.
6
Fine specificity of a proliferating T-cell clone activated by a conformational determinant of the I-Ek molecule.由I-Ek分子的构象决定簇激活的增殖性T细胞克隆的精细特异性。
Immunogenetics. 1982;15(4):399-412. doi: 10.1007/BF00364263.
7
T cell clones reactive with sperm whale myoglobin. Isolation of clones with specificity for individual determinants on myoglobin.与抹香鲸肌红蛋白反应的T细胞克隆。分离对肌红蛋白上单个决定簇具有特异性的克隆。
J Exp Med. 1981 Nov 1;154(5):1342-56. doi: 10.1084/jem.154.5.1342.
8
Role of the H-2 complex in induction of T helper cells in vivo. II Negative selection of discrete subgroups of T cells restricted by I-A and I-A/E determinants.H-2复合体在体内诱导T辅助细胞中的作用。II. 受I-A和I-A/E决定簇限制的T细胞离散亚群的阴性选择
J Exp Med. 1981 Apr 1;153(4):823-31. doi: 10.1084/jem.153.4.823.
9
Reconstitution of Ir genes, Ia antigens, and mixed lymphocyte reaction determinants by gene complementation.通过基因互补重建Ir基因、Ia抗原和混合淋巴细胞反应决定簇。
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1853-7. doi: 10.1073/pnas.78.3.1853.
10
Effects of blocking helper T cell induction in vivo with anti-Ia antibodies. Possible role of I-A/E hybrid molecules as restriction elements.用抗Ia抗体在体内阻断辅助性T细胞诱导的作用。I-A/E杂交分子作为限制元件的可能作用。
J Exp Med. 1980 Oct 1;152(4):996-1010. doi: 10.1084/jem.152.4.996.

本文引用的文献

1
Structural studies on the murine Ia alloantigens. IV. NH2-terminal sequence analysis of allelic products of the I-A and I-E/C subregions.小鼠Ia同种异体抗原的结构研究。IV. I-A和I-E/C亚区等位基因产物的NH2末端序列分析。
J Immunol. 1979 Jun;122(6):2232-7.
2
Analysis of H-2 and Ia molecules by two-dimensional gel electrophoresis.通过二维凝胶电泳分析H-2和Ia分子。
J Exp Med. 1977 Nov 1;146(5):1261-79. doi: 10.1084/jem.146.5.1261.
3
Monoclonal cytolytic T-cell lines.单克隆细胞毒性T细胞系
J Exp Med. 1979 Jan 1;149(1):273-8. doi: 10.1084/jem.149.1.273.
4
Cloned T-cell lines with specific cytolytic activity.具有特异性细胞溶解活性的克隆T细胞系。
Curr Top Microbiol Immunol. 1978;81:176-87. doi: 10.1007/978-3-642-67448-8_29.
5
Clones of alloreactive T cells.
Nature. 1978 Apr 13;272(5654):617-8. doi: 10.1038/272617a0.
6
Two-gene control of the expression of a murine Ia antigen.小鼠Ia抗原表达的双基因控制
J Exp Med. 1978 Oct 1;148(4):925-39. doi: 10.1084/jem.148.4.925.
7
In vitro secondary MLR. III: Hybrid histocompatibility determinants.体外二次混合淋巴细胞反应。III：杂种组织相容性决定簇。
J Immunol. 1978 Jul;121(1):259-64.
8
In vitro secondary mixed leukocyte reaction (MLR). II. Interaction MLR determinants expressed by F1 cells.体外二次混合淋巴细胞反应（MLR）。II. F1细胞表达的MLR决定簇之间的相互作用
Eur J Immunol. 1977 Jun;7(6):370-4. doi: 10.1002/eji.1830070609.
9
In vitro secondary MLR. I. Kinetics of proliferation and specificity of in vitro primed responder cells.体外二次混合淋巴细胞反应。I. 体外致敏反应细胞的增殖动力学及特异性。
J Immunol. 1977 Apr;118(4):1232-8.

克隆化的同种异体反应性T细胞识别的交叉反应性混合淋巴细胞反应决定簇。

Crossreactive mixed lymphocyte reaction determinants recognized by cloned alloreactive T cells.

作者信息

Fathman C G, Hengartner H

出版信息

Proc Natl Acad Sci U S A. 1979 Nov;76(11):5863-6. doi: 10.1073/pnas.76.11.5863.

DOI:10.1073/pnas.76.11.5863
PMID:93286
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC411752/
Abstract

We have isolated clones of alloreactive T cells by soft agar cloning of primed responder cells contained in serially restimulated, mixed lymphocyte cultures. These clones recognize unique mixed lymphocyte reaction (MLR) stimulating determinants present on (C57B/6 X A/J)F1 (B6A) spleen cells. By assaying the reactivity patterns of these clones on a panel of stimulator cells, we have identified at least three separate "specificities" of alloreactive T cell clones. Several clones exhibiting one of these three reactivity patterns have been isolated on many occasions from different experiments. Using such clones of alloreactive T cells, we have identified and are attempting to define crossreactive MLR stimulating determinants exhibited by a panel of stimulator cells. Recognition by certain clones of a shared MLR determinant(s) on B6A and DBA/2 and of the lack of this determinant(s) on B6 stimulator cells questions current concepts concerning the nature of MLR stimulating determinants and T cell recognition of alloantigens.

摘要

我们通过对连续再刺激的混合淋巴细胞培养物中含有的致敏应答细胞进行软琼脂克隆，分离出了同种异体反应性T细胞克隆。这些克隆识别存在于（C57B/6×A/J）F1（B6A）脾细胞上的独特混合淋巴细胞反应（MLR）刺激决定簇。通过检测这些克隆对一组刺激细胞的反应模式，我们确定了同种异体反应性T细胞克隆至少三种不同的“特异性”。在许多不同的实验中，多次分离出表现出这三种反应模式之一的几个克隆。利用这些同种异体反应性T细胞克隆，我们已经鉴定并正在试图确定一组刺激细胞所呈现的交叉反应性MLR刺激决定簇。某些克隆对B6A和DBA/2上共同的MLR决定簇的识别以及对B6刺激细胞上缺乏该决定簇的识别，对当前有关MLR刺激决定簇的性质和T细胞对同种异体抗原识别的概念提出了质疑。