Trinn C, Szöke B, Tóth T, Nagy J
Second Deptartment of Medicine, University Medical School Pécs, Hungary.
Acta Physiol Hung. 1996;84(4):469-70.
We report the case of a young alcoholic male whose first renal biopsy disclosed mesangiocapillary glomerulonephritis. One month later he took 1.5 g paracetamol to control the fever. Soon he got hospitalized due to toxicoderma, elevated liver and renal function tests. While the liver enzymes returned to normal, uremia developed. A repeated renal biopsy revealed severe interstitial inflammation, tubular atrophy. Haemodialysis was started and he got steroids (1 mg/kg body weight). He showed considerable recovery of renal function in some weeks. The case points to the possibility that paracetamol-even in therapeutic dosage-might result in hepatic and renal damage in alcoholics.
我们报告了一例年轻的酗酒男性病例，其首次肾活检显示为系膜毛细血管性肾小球肾炎。一个月后，他服用了1.5克对乙酰氨基酚来控制发热。不久后，他因中毒性表皮坏死松解症以及肝肾功能检查指标升高而住院。虽然肝酶恢复了正常，但出现了尿毒症。再次进行肾活检显示有严重的间质炎症和肾小管萎缩。于是开始进行血液透析，并给予他类固醇（1毫克/千克体重）。几周后他的肾功能有了显著恢复。该病例表明，即使是治疗剂量的对乙酰氨基酚，也可能对酗酒者造成肝和肾的损害。
