Xia S, Liu L, Feng C, Guo A
Laboratory of Visual Information Processing, Institute of Biophysics, Academia Sinica, Beijing, People's Republic of China.
Pharmacol Biochem Behav. 1997 Nov;58(3):727-35. doi: 10.1016/s0091-3057(97)00045-2.
Recent work on operant visual learning and memory in Drosophila has suggested at least three distinct memory phases. Trying to disrupt memory pharmacologically, we fed flies with ouabain or the depolarizing drugs potassium chloride (KCl), lithium chloride (LiCl) and monosodium glutamate for some specific time before training. The depolarizing drugs abolished memory very soon after training. Ouabain exerted no effect on memory within the first 20 min but abolished it more than 30 min after training. These drugs had no diminishing effects on the visual discrimination and behavioral performance of the flies during training. This result suggests that memory disruption may not be induced by nonspecific effects of the drugs. In addition, reversal training of the KCl-fed flies indicates that KCl appears not to impair the retrieval mechanism of flies. These results suggest that the specific disruptive effects of the drugs on memory formation and the existence of a short-term memory phase, are susceptible to disruption of the depolarizing drugs but unaffected by ouabain.
最近关于果蝇操作性视觉学习和记忆的研究表明至少存在三个不同的记忆阶段。为了从药理学角度干扰记忆，我们在训练前的特定时间用哇巴因或去极化药物氯化钾（KCl）、氯化锂（LiCl）和谷氨酸钠喂养果蝇。训练后不久，去极化药物就消除了记忆。哇巴因在训练后的前20分钟内对记忆没有影响，但在训练30分钟后消除了记忆。这些药物在训练期间对果蝇的视觉辨别和行为表现没有减弱作用。这一结果表明，记忆干扰可能不是由药物的非特异性作用引起的。此外，对喂食KCl的果蝇进行的反向训练表明，KCl似乎不会损害果蝇的记忆提取机制。这些结果表明，药物对记忆形成的特定破坏作用以及短期记忆阶段的存在，容易受到去极化药物的干扰，但不受哇巴因的影响。
