Xia S Z, Feng C H, Guo A K
Laboratory of Visual Information Processing, Institute of Biophysics, Academia Sinica, Beijing, People's Republic of China.
Pharmacol Biochem Behav. 1998 Aug;60(4):809-16. doi: 10.1016/s0091-3057(98)00060-4.
Previous work on classical olfactory learning and memory in flies has suggested at least four distinct phases of memory consolidation. Similarly, our behavioral and pharmacological analyses also provided clear evidence for at least four pharmacologically distinct memory phases in flies after operant conditioning. Anesthesia-resistant memory (ARM) is present between about 20 and 120 min after training, and susceptible to disruption by the ATPase deactivating chemicals such as ouabain and ethacrynic acid (EA). Long-term memory (LTM) is activated at least 150 min after training, and can be disrupted by protein synthesis inhibitors such as cycloheximide (CXM). In addition, a very short-term memory (pre-STM) is demonstrated by feeding flies with potassium chloride (KCl), which has been shown to disrupt the short-term memory. These observations confirm our previous argument that memory formation in flies involves an intricate, multiple-phase pathway of consolidation.
以往关于果蝇经典嗅觉学习和记忆的研究表明，记忆巩固至少有四个不同阶段。同样，我们的行为学和药理学分析也提供了明确证据，表明果蝇在操作性条件反射后至少有四个药理学上不同的记忆阶段。麻醉抗性记忆（ARM）在训练后约20至120分钟出现，易被哇巴因和依他尼酸（EA）等ATP酶失活化学物质破坏。长期记忆（LTM）在训练后至少150分钟被激活，可被环己酰亚胺（CXM）等蛋白质合成抑制剂破坏。此外，通过给果蝇喂食氯化钾（KCl）可证明存在极短期记忆（pre-STM），氯化钾已被证明会破坏短期记忆。这些观察结果证实了我们之前的观点，即果蝇的记忆形成涉及一个复杂的多阶段巩固途径。
