Friedl T K, Flaig M J, Ruzicka T, Rupec R A
Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, Frauenlobstr. 9-11, 80337, München.
Hautarzt. 2011 Jan;62(1):40-5. doi: 10.1007/s00105-010-1961-4.
Lichen planus is a chronic mucocutaneous T-cell-mediated disease, whose cause is still unknown. The first case of lichen planus that transformed into squamous cell carcinoma was reported in 1903. We present three patients in whom squamous cell carcinomas were identified in chronic lichen planus. The world literature includes at least 91 cases, including our three cases. In an epidemiological study, no significant risk of transformation of cutaneous lichen planus into squamous cell carcinomas was found. In contrast, there is a significantly higher risk of malignant transformation in mucosal lichen planus, so that the WHO had graded mucosal lichen planus as a premalignant condition.
扁平苔藓是一种慢性黏膜皮肤T细胞介导的疾病，其病因尚不清楚。1903年报道了首例扁平苔藓转变为鳞状细胞癌的病例。我们报告了3例在慢性扁平苔藓中发现鳞状细胞癌的患者。世界文献中至少有91例，包括我们的3例。在一项流行病学研究中，未发现皮肤扁平苔藓转变为鳞状细胞癌的显著风险。相比之下，黏膜扁平苔藓发生恶性转化的风险显著更高，因此世界卫生组织已将黏膜扁平苔藓列为癌前病变。
