Haenen Caroline Cecile Pauline, Buurma Aletta Atje Jacoba, Genders Roel Erik, Quint Koen D
Department of Dermatology, LUMC, Leiden, The Netherlands.
Department of Pathology, LUMC, Leiden, The Netherlands.
BMJ Case Rep. 2018 Jul 11;2018:bcr-2017-224044. doi: 10.1136/bcr-2017-224044.
Hypertrophic lichen planus (HLP) is a chronic T-cell-mediated inflammatory disease characterised by pruritic hypertrophic or verrucous plaques on the lower limbs. We report a case of an 87-year-old woman with a 12-year history of HLP on both lower legs presenting with malignant transformation of one lesion into a squamous cell carcinoma (SCC). Malignancy developing in cutaneous lichen planus is rare, with less than 50 cases reported in the literature. This case highlights the need to be aware of suspicious changes in long-standing HLP to allow early detection of a developing SCC.
肥厚性扁平苔藓（HLP）是一种慢性T细胞介导的炎症性疾病，其特征为下肢出现瘙痒性肥厚性或疣状斑块。我们报告一例87岁女性，双下肢HLP病史12年，其中一个皮损发生恶变，转变为鳞状细胞癌（SCC）。皮肤扁平苔藓发生恶变很罕见，文献报道不足50例。该病例强调，需要留意长期HLP的可疑变化，以便早期发现进展中的SCC。
