肥厚性扁平苔藓中发生的鳞状细胞癌。
Squamous cell carcinoma arising in hypertrophic lichen planus.
作者信息
Haenen Caroline Cecile Pauline, Buurma Aletta Atje Jacoba, Genders Roel Erik, Quint Koen D
机构信息
Department of Dermatology, LUMC, Leiden, The Netherlands.
Department of Pathology, LUMC, Leiden, The Netherlands.
出版信息
BMJ Case Rep. 2018 Jul 11;2018:bcr-2017-224044. doi: 10.1136/bcr-2017-224044.
Abstract
Hypertrophic lichen planus (HLP) is a chronic T-cell-mediated inflammatory disease characterised by pruritic hypertrophic or verrucous plaques on the lower limbs. We report a case of an 87-year-old woman with a 12-year history of HLP on both lower legs presenting with malignant transformation of one lesion into a squamous cell carcinoma (SCC). Malignancy developing in cutaneous lichen planus is rare, with less than 50 cases reported in the literature. This case highlights the need to be aware of suspicious changes in long-standing HLP to allow early detection of a developing SCC.
摘要
肥厚性扁平苔藓（HLP）是一种慢性T细胞介导的炎症性疾病，其特征为下肢出现瘙痒性肥厚性或疣状斑块。我们报告一例87岁女性，双下肢HLP病史12年，其中一个皮损发生恶变，转变为鳞状细胞癌（SCC）。皮肤扁平苔藓发生恶变很罕见，文献报道不足50例。该病例强调，需要留意长期HLP的可疑变化，以便早期发现进展中的SCC。
相似文献
1
Squamous cell carcinoma arising in hypertrophic lichen planus.肥厚性扁平苔藓中发生的鳞状细胞癌。
BMJ Case Rep. 2018 Jul 11;2018:bcr-2017-224044. doi: 10.1136/bcr-2017-224044.
2
Widely metastatic squamous cell carcinoma originating from malignant transformation of hypertrophic lichen planus in a 24-year-old woman: case report and review of the literature.一名24岁女性肥厚性扁平苔藓恶变引发的广泛转移性鳞状细胞癌：病例报告及文献复习
Pediatr Dermatol. 2015 May-Jun;32(3):e98-101. doi: 10.1111/pde.12549. Epub 2015 Mar 5.
3
Squamous Cell Carcinoma Arising in Hypertrophic Lichen Planus: A Review and Analysis of 38 Cases.肥厚性扁平苔藓中发生的鳞状细胞癌：38例病例的回顾与分析
Dermatol Surg. 2015 Dec;41(12):1411-8. doi: 10.1097/DSS.0000000000000565.
4
Twice malignant transformation of hypertrophic lichen planus.肥厚性扁平苔藓的双重恶性转化
Ann Agric Environ Med. 2012;19(4):787-9.
5
Giant keratoacanthoma arising in hypertrophic lichen planus.肥厚性扁平苔藓中发生的巨大角化棘皮瘤。
Australas J Dermatol. 2003 Nov;44(4):267-9. doi: 10.1046/j.1440-0960.2003.00006.x.
6
Malignant Transformation of Hypertrophic Lichen Planus in a Young Pregnant Woman: A Case Report.一名年轻孕妇肥厚性扁平苔藓的恶性转化：病例报告
Int J Low Extrem Wounds. 2020 Dec;19(4):388-390. doi: 10.1177/1534734619881584. Epub 2019 Oct 18.
7
Verrucous carcinoma in association with hypertrophic lichen planus.疣状癌合并肥厚性扁平苔藓。
Clin Exp Dermatol. 1997 Jan;22(1):23-5. doi: 10.1046/j.1365-2230.1997.d01-241.x.
8
[Development of squamous epithelial carcinoma on the lower leg in long-term verrucous lichen planus].[长期疣状扁平苔藓患者小腿部鳞状上皮癌的发生]
Wien Klin Wochenschr. 2003 Apr 30;115(7-8):267-70. doi: 10.1007/BF03040327.
9
[Squamous epithelial carcinoma at the site of lichen ruber hypertrophicus of the glans penis].阴茎头肥厚性红苔藓部位的鳞状上皮癌
Hautarzt. 1991 Feb;42(2):112-5.
10
Squamous cell carcinoma developing within lichen planus of the penis. Treatment with Mohs micrographic surgery.阴茎扁平苔藓内发生的鳞状细胞癌。采用莫氏显微外科手术治疗。
J Dermatol Surg Oncol. 1994 Apr;20(4):272-6. doi: 10.1111/j.1524-4725.1994.tb01624.x.
引用本文的文献
1
Hypertrophic Lichen Planus and Hypertrophic Skin Lesions Associated with Histological Lichenoid Infiltrate: A Case Report and Literature Review.肥厚性扁平苔藓及伴有组织学苔藓样浸润的肥厚性皮肤病变：病例报告及文献综述
Dermatopathology (Basel). 2025 Feb 25;12(1):8. doi: 10.3390/dermatopathology12010008.
2
Case report: Hypertrophic lichen planus initially misdiagnosed as squamous cell carcinoma.病例报告：肥厚性扁平苔藓最初被误诊为鳞状细胞癌。
Front Med (Lausanne). 2024 May 15;11:1342501. doi: 10.3389/fmed.2024.1342501. eCollection 2024.
3
Hypertrophic Lichen Planus: A Precursor Lesion for Squamous Cell Carcinoma.肥厚性扁平苔藓：鳞状细胞癌的前驱病变。
Cureus. 2024 Mar 3;16(3):e55450. doi: 10.7759/cureus.55450. eCollection 2024 Mar.
4
Current Understanding of Flavonoids in Cancer Therapy and Prevention.黄酮类化合物在癌症治疗与预防中的当前认识
Metabolites. 2023 Mar 27;13(4):481. doi: 10.3390/metabo13040481.
5
To treat or not to treat: PD-L1 inhibitor-induced keratoacanthoma and squamous cell carcinoma.治疗还是不治疗：程序性死亡受体1配体（PD-L1）抑制剂诱发的角化棘皮瘤和鳞状细胞癌
Arch Dermatol Res. 2023 May;315(4):903-915. doi: 10.1007/s00403-022-02468-3. Epub 2022 Nov 17.
6
Recurrent bilateral cutaneous squamous cell carcinoma arising within hypertrophic lichen planus with metastasis while on cemiplimab.在使用西米普利单抗治疗期间，肥厚性扁平苔藓内出现复发性双侧皮肤鳞状细胞癌并发生转移。
JAAD Case Rep. 2022 Sep 5;29:55-58. doi: 10.1016/j.jdcr.2022.08.046. eCollection 2022 Nov.
7
Flavonoids: A Myth or a Reality for Cancer Therapy?类黄酮：癌症治疗的神话还是现实？
Molecules. 2021 Jun 11;26(12):3583. doi: 10.3390/molecules26123583.
8
Giant Squamous Cell Carcinoma on Chronic Lichen Planus on the Ankle - A Case Report and Short Literature Review.踝关节慢性扁平苔藓上的巨大鳞状细胞癌——病例报告及文献综述
Open Access Maced J Med Sci. 2019 Aug 19;7(18):3061-3063. doi: 10.3889/oamjms.2019.553. eCollection 2019 Sep 30.
本文引用的文献
1
Squamous Cell Carcinoma Arising in Hypertrophic Lichen Planus: A Review and Analysis of 38 Cases.肥厚性扁平苔藓中发生的鳞状细胞癌：38例病例的回顾与分析
Dermatol Surg. 2015 Dec;41(12):1411-8. doi: 10.1097/DSS.0000000000000565.
2
Widely metastatic squamous cell carcinoma originating from malignant transformation of hypertrophic lichen planus in a 24-year-old woman: case report and review of the literature.一名24岁女性肥厚性扁平苔藓恶变引发的广泛转移性鳞状细胞癌：病例报告及文献复习
Pediatr Dermatol. 2015 May-Jun;32(3):e98-101. doi: 10.1111/pde.12549. Epub 2015 Mar 5.
3
Twice malignant transformation of hypertrophic lichen planus.肥厚性扁平苔藓的双重恶性转化
Ann Agric Environ Med. 2012;19(4):787-9.
4
Squamous cell carcinoma arising from hypertrophic lichen planus.肥厚性扁平苔藓引发的鳞状细胞癌。
J Eur Acad Dermatol Venereol. 2006 Jul;20(6):745-6. doi: 10.1111/j.1468-3083.2006.01500.x.
5
Squamous cell carcinoma as a complication of long-standing hypertrophic lichen planus.鳞状细胞癌作为长期肥厚性扁平苔藓的一种并发症。
Int J Dermatol. 2005 Sep;44(9):773-4. doi: 10.1111/j.1365-4632.2004.02202.x.
6
A case of hypertrophic lichen ruber planus of the leg complicated by a squamous cell carcinoma.1例腿部肥厚性扁平苔藓合并鳞状细胞癌。
Int J Dermatol. 2003 May;42(5):415-6. doi: 10.1046/j.1365-4362.2003.01791.x.
7
Metastatic cutaneous squamous cell carcinoma arising from a previous area of chronic hypertrophic lichen planus.源于先前慢性肥厚性扁平苔藓区域的转移性皮肤鳞状细胞癌。
Dermatol Online J. 2003 Feb;9(1):10.
8
[Squamous epithelial cancer in lichen ruber hypertrophicus--a case report with a review of the literature].[肥厚性扁平苔藓中的鳞状上皮癌——一例报告并文献复习]
Z Hautkr. 1986 Mar 15;61(6):394-402.
9
Lichen planus and malignancy. An epidemiologic study of 2071 patients and a review of the literature.扁平苔藓与恶性肿瘤。对2071例患者的流行病学研究及文献综述。
Arch Dermatol. 1991 Nov;127(11):1684-8. doi: 10.1001/archderm.127.11.1684.
Zotero 插件