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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

O'Connor W J, Summerill R A

J Physiol. 1976 Mar;256(1):93-102. doi: 10.1113/jphysiol.1976.sp011313.

After a meal of meat (10g/kg), urea excretion in dogs increased by about 200%, plasma urea by 60% and exogenous creatinine clearance by 40% in comparison with control experiments. 2. Urea, given by stomach tube in doses producing the same increase in plasma urea, caused urea excretion to increase by only 90%, with no increase in creatinine clearance. With the increased glomerular filtration rate after meat there was added excretion of urea. 3. In control experiments and after urea, the rate of excretion of urea was directly proportional to plasma urea. The ratio urea clearance/creatinine clearance, was 0-45. 4. After meat, urea clearance increased more than creatinine clearance, the ratio increasing to 0-55, i.e. a smaller fraction of the filtered urea was re-absorbed after meat. 5. After meat, 10g/kg, the rate of urea production rose to 230-600 mumole/min for 4-6 hr.

给狗喂食10克/千克肉类后，与对照实验相比，狗的尿素排泄量增加了约200%，血浆尿素增加了60%，外源性肌酐清除率增加了40%。2. 通过胃管给予能使血浆尿素产生相同增幅的剂量的尿素，仅使尿素排泄量增加了90%，肌酐清除率未增加。进食肉类后肾小球滤过率增加，同时尿素排泄增加。3. 在对照实验和给予尿素后，尿素排泄率与血浆尿素直接成正比。尿素清除率与肌酐清除率的比值为0.45。4. 进食肉类后，尿素清除率的增加幅度大于肌酐清除率，该比值增至0.55，即进食肉类后被重吸收的滤过尿素比例更小。5. 给狗喂食10克/千克肉类后，尿素生成率在4至6小时内升至230 - 600微摩尔/分钟。

O'Connor W J, Summerill R A

J Physiol. 1976 Mar;256(1):93-102. doi: 10.1113/jphysiol.1976.sp011313.

After a meal of meat (10g/kg), urea excretion in dogs increased by about 200%, plasma urea by 60% and exogenous creatinine clearance by 40% in comparison with control experiments. 2. Urea, given by stomach tube in doses producing the same increase in plasma urea, caused urea excretion to increase by only 90%, with no increase in creatinine clearance. With the increased glomerular filtration rate after meat there was added excretion of urea. 3. In control experiments and after urea, the rate of excretion of urea was directly proportional to plasma urea. The ratio urea clearance/creatinine clearance, was 0-45. 4. After meat, urea clearance increased more than creatinine clearance, the ratio increasing to 0-55, i.e. a smaller fraction of the filtered urea was re-absorbed after meat. 5. After meat, 10g/kg, the rate of urea production rose to 230-600 mumole/min for 4-6 hr.

给狗喂食10克/千克肉类后，与对照实验相比，狗的尿素排泄量增加了约200%，血浆尿素增加了60%，外源性肌酐清除率增加了40%。2. 通过胃管给予能使血浆尿素产生相同增幅的剂量的尿素，仅使尿素排泄量增加了90%，肌酐清除率未增加。进食肉类后肾小球滤过率增加，同时尿素排泄增加。3. 在对照实验和给予尿素后，尿素排泄率与血浆尿素直接成正比。尿素清除率与肌酐清除率的比值为0.45。4. 进食肉类后，尿素清除率的增加幅度大于肌酐清除率，该比值增至0.55，即进食肉类后被重吸收的滤过尿素比例更小。5. 给狗喂食10克/千克肉类后，尿素生成率在4至6小时内升至230 - 600微摩尔/分钟。