Mills K C
Department of Emergency Medicine and Medical Toxicology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Crit Care Clin. 1997 Oct;13(4):763-83. doi: 10.1016/s0749-0704(05)70368-7.
Serotonin syndrome is characterized by varied degrees of cognitive, autonomic, and neuromuscular dysfunction and can only be produced by drug therapy that increases central nervous system serotonin neurotransmission. Information gained from a retrospective review of 127 cases of serotonin syndrome is presented. It is not uncommon for severe cases of serotonin syndrome to be confused with neuroleptic malignant syndrome. Treatment is mainly supportive, but specific pharmacologic therapy with serotonin antagonists may be potentially beneficial.
血清素综合征的特征是存在不同程度的认知、自主神经和神经肌肉功能障碍，且只能由增加中枢神经系统血清素神经传递的药物治疗引发。本文呈现了对127例血清素综合征病例进行回顾性研究所得的信息。血清素综合征的严重病例被误诊为抗精神病药恶性综合征的情况并不少见。治疗主要是支持性的，但使用血清素拮抗剂进行特异性药物治疗可能有益。
