Prus D, Rosenberg A E, Blumenfeld A, Udassin R, Ne'eman Z, Young R H, Ariel I
Department of Pathology, Hadassah University Hospital, Mount Scopus and the Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Am J Surg Pathol. 1997 Oct;21(10):1231-5. doi: 10.1097/00000478-199710000-00015.
Vascular tumors of the female genital tract are uncommon, and only a few cases have been reported in the ovary. We describe herein, an unusual tumor of the ovary: infantile hemangioendothelioma (cellular hemangioma of infancy) in a newborn. The tumor consisted of well-formed blood vessels and proliferating endothelial cells that were arranged in solid cordlike structures. The tumor permeated the ovarian stroma and entrapped normal ovarian follicles. By immunohistochemistry the neoplastic cells expressed factor VIII, CD34, and alpha smooth-muscle actin, and ultrastructurally they had the features of endothelial cells that were focally associated with pericytes. We examined simple sequence repeat (SSR) polymorphic markers in the tumor tissue, as well as in the patient's and parents' blood. The informative SSR markers were found to be identical in the tumor and in the patient's somatic cells. We suggest that the tumor described herein is a congenital infantile hemangioendothelioma arising from ovarian parenchymal cells rather than a teratoma originating from germ cells. A similar morphologic lesion has been described recently in the ovary and interpreted as monodermal teratoma composed of vascular tissue.
女性生殖道血管肿瘤并不常见，卵巢中仅有少数病例报道。我们在此描述一例罕见的卵巢肿瘤：一名新生儿的婴儿型血管内皮瘤（婴儿型细胞性血管瘤）。肿瘤由形态良好的血管和增殖的内皮细胞组成，这些细胞排列成实性条索状结构。肿瘤浸润卵巢间质并包绕正常卵巢滤泡。免疫组化显示肿瘤细胞表达因子VIII、CD34和α平滑肌肌动蛋白，超微结构显示它们具有内皮细胞特征，且局部与周细胞相关。我们检测了肿瘤组织以及患者及其父母血液中的简单序列重复（SSR）多态性标记。发现肿瘤与患者体细胞中的信息性SSR标记相同。我们认为本文所述肿瘤是起源于卵巢实质细胞的先天性婴儿型血管内皮瘤，而非起源于生殖细胞的畸胎瘤。最近在卵巢中也描述了类似的形态学病变，并被解释为由血管组织组成的单胚层畸胎瘤。
