通过年度CT评估严重α1-抗胰蛋白酶缺乏症患者肺气肿的进展情况。
Progress of emphysema in severe alpha 1-antitrypsin deficiency as assessed by annual CT.
作者信息
Dirksen A, Friis M, Olesen K P, Skovgaard L T, Sørensen K
机构信息
Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark.
出版信息
Acta Radiol. 1997 Sep;38(5):826-32. doi: 10.1080/02841859709172418.
PURPOSE
To assess serial CT as a measure of the progress of emphysema in patients with severe alpha 1-antitrypsin deficiency (phenotype PiZ).
MATERIAL AND METHODS
In a randomized placebo-controlled study of alpha 1-antitrypsin augmentation therapy, 22 patients with moderate emphysema were followed for 2-4 years with an annual lung CT. The images were analysed by means of semiautomatic lung detection, and the degree of emphysema was quantitated by the density-mask and the percentile methods. The influence of lung volume was standardised by a regression model.
RESULTS
A highly significant decline in Hounsfield units (HU) was found in low-density areas, corresponding to a mean (SE) annual loss of lung tissue of 2.1 (0.4) g/l lung volume. Analysis of a single slice at 5 cm below the level of the carina gave comparable results: 2.4 (0.4) g/l.
CONCLUSION
Serial CT is a sensitive measure of the progress of emphysema in patients with severe alpha 1-antitrypsin deficiency.
目的
评估连续CT作为重度α1-抗胰蛋白酶缺乏症（PiZ表型）患者肺气肿进展的一种测量方法。
材料与方法
在一项α1-抗胰蛋白酶增强疗法的随机安慰剂对照研究中，对22例中度肺气肿患者进行了为期2至4年的年度肺部CT随访。通过半自动肺部检测对图像进行分析，并采用密度掩码法和百分位数法对肺气肿程度进行定量。通过回归模型对肺容积的影响进行标准化。
结果
在低密度区域发现亨氏单位（HU）显著下降，相当于肺组织平均（标准误）每年损失2.1（0.4）g/升肺容积。在隆突水平以下5 cm处分析单个层面得到了类似结果：2.4（0.4）g/升。
结论
连续CT是重度α1-抗胰蛋白酶缺乏症患者肺气肿进展的一种敏感测量方法。
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