亚胺培南处理的肠出血性大肠杆菌中志贺样毒素（维罗毒素）和内毒素的低水平释放。
Low-level release of Shiga-like toxin (verocytotoxin) and endotoxin from enterohemorrhagic Escherichia coli treated with imipenem.
作者信息
Takahashi K, Narita K, Kato Y, Sugiyama T, Koide N, Yoshida T, Yokochi T
机构信息
Department of Microbiology and Immunology, Aichi Medical University, Nagakute, Japan.
出版信息
Antimicrob Agents Chemother. 1997 Oct;41(10):2295-6. doi: 10.1128/AAC.41.10.2295.
Abstract
Shiga-like toxin (SLT) and endotoxin may participate in the pathogenesis of enterohemorrhagic Escherichia coli (EHEC) infection. Levels of release of SLT and endotoxin from EHEC treated in vitro with antibiotics were estimated. There were differential levels of release of SLT and endotoxin from EHEC treated with different antibiotics. Treatment of EHEC strains, namely, E. coli O157, O111, and O26, with imipenem induced much lower levels of release of SLT and endotoxin than treatment with ceftazidime.
摘要
志贺样毒素（SLT）和内毒素可能参与肠出血性大肠杆菌（EHEC）感染的发病机制。对体外经抗生素处理的EHEC释放SLT和内毒素的水平进行了评估。用不同抗生素处理的EHEC释放SLT和内毒素的水平存在差异。用亚胺培南处理EHEC菌株，即大肠杆菌O157、O111和O26，与用头孢他啶处理相比，诱导的SLT和内毒素释放水平要低得多。
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