norA基因敲除的金黄色葡萄球菌对喹诺酮类药物的敏感性
Quinolone susceptibility of norA-disrupted Staphylococcus aureus.
作者信息
Yamada H, Kurose-Hamada S, Fukuda Y, Mitsuyama J, Takahata M, Minami S, Watanabe Y, Narita H
机构信息
Research Laboratories, Toyama Chemical Co. Ltd., Toyama City, Japan.
出版信息
Antimicrob Agents Chemother. 1997 Oct;41(10):2308-9. doi: 10.1128/AAC.41.10.2308.
Abstract
The MIC of norfloxacin for the norA-disrupted mutant termed RDN1, obtained from quinolone-susceptible Staphylococcus aureus RN4220, was eightfold lower than that for RN4220. The increase in susceptibility was related to an increase of drug accumulation by RDN1. These results indicate that NorA plays an important role in the susceptibility of quinolone-susceptible S. aureus to selected quinolones.
摘要
从喹诺酮敏感的金黄色葡萄球菌RN4220获得的norA基因破坏突变体RDN1对诺氟沙星的最低抑菌浓度（MIC）比RN4220低八倍。敏感性的增加与RDN1药物积累的增加有关。这些结果表明，NorA在喹诺酮敏感的金黄色葡萄球菌对所选喹诺酮的敏感性中起重要作用。
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